Results 181 to 190 of about 310,837 (298)

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy. [PDF]

J Nanobiotechnology
Zhang J, Zhang YP, Sun Q, Wang Y, Mei D, Wang X, Su Y, Tian Y, Huo R, Liu D, Liu S, Baldan M, Zhang S, Cui C.   +13 more
europepmc   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target. [PDF]

Biomedicines
Sierra-Sánchez VM, Blancas-Napoles CM, Sánchez-Maldonado AD, Medina I, Romero-Nava R, Huang F, Hong E, Aguilera-Méndez A, Ocampo-Ortega SA, Villafaña S.   +9 more
europepmc   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol. [PDF]

Nat Commun
Johansson JM, Du Rietz H, Hedlund H, Eriksson HC, Oude Blenke E, Pote A, Harun S, Nordenfelt P, Lindfors L, Wittrup A.   +9 more
europepmc   +1 more source

Adenovirus-Mediated Transfer of siRNA against Survivin Induced Apoptosis and Attenuated Tumor Cell Growth in Vitro and in Vivo [PDF]

, 2004
Hiroaki Uchida, Toshihiro Tanaka, Katsunori Sasaki, Kazunori Kato, Hironari Dehari, Yoshinori Ito, Masayoshi Kobune, Makoto Miyagishi, Kazunari Taira, Hideaki Tahara, Hirofumi Hamada   +10 more
openalex   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Beclin1-mediated vascular autophagy negatively regulates angiogenesis and secondary neural damage in the thalamus following cerebral cortical infarction. [PDF]

IBRO Neurosci Rep
Liu M, Chen Y, Fan X, Gu J, Xing S.
europepmc   +1 more source

Anti-RhoA and Anti-RhoC siRNAs Inhibit the Proliferation and Invasiveness of MDA-MB-231 Breast Cancer Cells in Vitro and in Vivo

, 2004
J.-Y. Pillé, Christophe Denoyelle, Julia Varet, J.‐R. Bertrand, J. Soria, Paule Opolon, Lu H, Linda-Louise Pritchard, J. P. Vannier, Claude Malvy, Claudine Soria, H. Li   +11 more
openalex   +1 more source