Results 191 to 200 of about 527,047 (339)

Phase 2‐3 Trial: Prevention of the Progression to Moderate and Severe COVID‐19 in SARS‐CoV‐2‐Infected Non‐Hospitalized Adults With Inhaled siRNA‐Based MIR 19 [PDF]

Musa Khaitov, Alexandra Nikonova, В. П. Смирнов, I. P. Shilovsky, И.А. Кофиади, Ellina Ruzanova, Valeriya Aleksandrovna Teplykh, Denis Makarov, A. Vertichikh, S. V. Teplykh, Diana Alpenidze, E.A. Muldagalieva, E. N. Simakina, T. Ivanushkina, К. А. Захаров, L. I. Melnikova, D. D. Medvedev, Oleg Zuev, D.А. Kudlаy, Daria S. Kruchko, Igor Berzin, Rudolf Valenta, Veronika Skvortsova   +22 more
openalex   +1 more source

Combination anticancer nanopreparations of novel proapoptotic drug, TRAIL and siRNA [PDF]

, 2013
Robert D. Riehle
openalex   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models. [PDF]

Int J Mol Sci
Kiseleva V, Vishnyakova P, Elchaninov A, Kiselev I, Sukhikh G, Fatkhudinov T.   +5 more
europepmc   +1 more source

1023. Chitosan Oligomers as siRNA Delivery Systems In Vitro

, 2007

openalex   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma <i>in vivo</i>. [PDF]

NAR Cancer
Wang D, Jia W, Lian J, Zhang J, Ren X, Wang Z, Liu W, Zhou C, Xu J, Tian W, Lu PY, Evans DM.   +11 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo. [PDF]

Int J Cell Biol
Bhakta-Yadav MS, Brown TL.
europepmc   +1 more source

Multifunctional Polymeric Micelles Co-loaded with Anti–Survivin siRNA and Paclitaxel Overcome Drug Resistance in an Animal Model of Ovarian Cancer [PDF]

, 2015
Giuseppina Salzano, Gemma Navarro, Malav Trivedi, Giuseppe De Rosa, Vladimir P. Torchilin   +4 more
openalex   +1 more source