Results 291 to 300 of about 527,047 (339)

Photothermal nanoparticles delivering heat-triggered siRNA for tumor therapy. [PDF]

Ann Med Surg (Lond)
Amin F, Imran A, Mahato RK.
europepmc   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress. [PDF]

Viruses
Anand LK, Djurkovic MA, Shepley-McTaggart A, Shtanko O, Harty RN.   +4 more
europepmc   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer. [PDF]

Mol Pharm
Lin ZI, Tsai TH, Wu LH, Lu CH, Hsu CY, Liang H, Lin HY, Fang YP, Law WC, Chang CH, Liou HE, Yang C, Cheng PW, Lee CH, Chen CK.   +14 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Design and <i>in vitro</i> validation of Brome mosaic -virus-like particles for gene delivery and immunomodulation of melanoma. [PDF]

Mater Today Bio
Elbadri K, Fuscielo M, Hamdan F, Cheng R, Feola S, Bokharaie H, D'Amico C, Molinaro G, Correia A, Wang S, Jeltsch M, Cerullo V, Santos HA.   +12 more
europepmc   +1 more source

Hydrolytically Stable Cationic Bis-MPA Dendrimers as Efficient Transfectants for Glioblastoma Cells and Primary Astrocytes. [PDF]

Biomacromolecules
Buendía A, Sanz Del Olmo N, Rodríguez-Clemente I, Wohlert J, Sztandera K, San Jacinto García J, Namata F, Malkoch M, Ceña V.   +8 more
europepmc   +1 more source

Functional Characterization of Suppressor of Cytokine Signalling 6 and Its Interaction with Erythropoietin Receptor in Colorectal Cancer Cells. [PDF]

Cancers (Basel)
Al-Bahri A, Zadjali F, Hanif S, Alharthi Z, Sakr H, Al-Kharusi A.   +5 more
europepmc   +1 more source

Approach to Design of Potent RNA Interference-Based Preparations Against Hepatocellular Carcinoma-Related Genes. [PDF]

Int J Mol Sci
Chernov PV, Ivanov VN, Dmitriev NA, Gusev AE, Kovchina VI, Gongadze IS, Kholstov AV, Popova MV, Kudlay DA, Kryuchko DS, Kofiadi IA, Khaitov MR.   +11 more
europepmc   +1 more source