Results 81 to 90 of about 141,854 (198)
Improvement of 5-fluorouracil chemosensitivity in colorectal cancer cells by siRNA-mediated silencing of STAT6 oncogene [PDF]
Objective(s): Colorectal cancer (CRC) remains a major health concern worldwide due to its high incidence, mortality rate, and resistance to conventional treatments.
Omid Rahbar Farzam+8 more
doaj +1 more source
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate [PDF]
Sayda M. Elbashir
openalex +1 more source
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, provided a safe and efficient delivery is available. In particular, specific delivery to target cells is critical for achieving high therapeutic efficacy ...
Yiwen Dong+15 more
semanticscholar +1 more source
In this paper, the self-assembled folate-biotin-quaternized starch nanoparticles (FBqS NPs) were used as carrier system of doxorubicin (DOX) and siRNAIGF1R for the codelivery of both into human lung adenocarcinoma cell lines (A549 cells) in vitro.
Liangping Li+8 more
doaj +1 more source
Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi [PDF]
Javier Martı́nez+4 more
openalex +1 more source
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
RNAi-based therapeutics show promising clinical data for treatment of liver-associated disorders. However, siRNA delivery into extra-hepatic tissues remains an obstacle, limiting the use of siRNA-based therapies.
Annabelle Biscans+6 more
semanticscholar +1 more source
Induction of apoptosis in HeLa cells with siRNA expression vector targeted against bcl-2 [PDF]
T. Futami+3 more
openalex +1 more source
AIM To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy.
Mingzhen Zhang+4 more
semanticscholar +1 more source
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA [PDF]
Xiaoqi Liu, Raymond L. Erikson
openalex +1 more source
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues.
M. Hassler+19 more
semanticscholar +1 more source