Results 81 to 90 of about 141,854 (198)

Improvement of 5-fluorouracil chemosensitivity in colorectal cancer cells by siRNA-mediated silencing of STAT6 oncogene [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Colorectal cancer (CRC) remains a major health concern worldwide due to its high incidence, mortality rate, and resistance to conventional treatments.
Omid Rahbar Farzam, Behzad Baradaran, Bahman Akbari, Soozan Najafi, Mohammad Amini, AmirHossein Yari, Reza Dabbaghipour, Vahid Pourabdollah Kaleybar Pourabdollah Kaleybar, Shiva Ahdi Khosroshahi   +8 more
doaj   +1 more source

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate [PDF]

, 2001
Sayda M. Elbashir
openalex   +1 more source

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy.

Journal of the American Chemical Society, 2018
Small interfering RNA (siRNA) is emerging as a novel therapeutic for treating various diseases, provided a safe and efficient delivery is available. In particular, specific delivery to target cells is critical for achieving high therapeutic efficacy ...
Yiwen Dong, Tianzhu Yu, Ling Ding, E. Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peizhuo Chen, D. Marson, Yifan Jiang, S. Giorgio, S. Pricl, Xiaoxuan Liu, P. Rocchi, Ling Peng   +15 more
semanticscholar   +1 more source

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

Drug Delivery, 2019
In this paper, the self-assembled folate-biotin-quaternized starch nanoparticles (FBqS NPs) were used as carrier system of doxorubicin (DOX) and siRNAIGF1R for the codelivery of both into human lung adenocarcinoma cell lines (A549 cells) in vitro.
Liangping Li, Suoju He, Lizhen Yu, Ezzat H Elshazly, Hui Wang, Kuanmin Chen, Song Zhang, Lixia Ke, Renmin Gong   +8 more
doaj   +1 more source

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi [PDF]

, 2002
Javier Martı́nez, Agnieszka Patkaniowska, Henning Urlaub, Reinhard Lührmann, Thomas Tuschl   +4 more
openalex   +1 more source

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

bioRxiv, 2018
RNAi-based therapeutics show promising clinical data for treatment of liver-associated disorders. However, siRNA delivery into extra-hepatic tissues remains an obstacle, limiting the use of siRNA-based therapies.
Annabelle Biscans, Andrew H Coles, R. Haraszti, Dimas Echeverria, M. Hassler, Maire F. Osborn, A. Khvorova   +6 more
semanticscholar   +1 more source

Induction of apoptosis in HeLa cells with siRNA expression vector targeted against bcl-2 [PDF]

, 2002
T. Futami, Makoto Miyagishi, Minoru Seki, Kazunari Taira   +3 more
openalex   +1 more source

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis.

Nanomedicine, 2017
AIM To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy.
Mingzhen Zhang, Xiaoyu Wang, Moon K Han, James F Collins, D. Merlin   +4 more
semanticscholar   +1 more source

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA [PDF]

, 2002
Xiaoqi Liu, Raymond L. Erikson
openalex   +1 more source

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Nucleic Acids Research, 2018
Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues.
M. Hassler, A. Turanov, J. Alterman, R. Haraszti, Andrew, H. Coles, Maire F. Osborn, Dimas Echeverria, Mehran Nikan, William E. Salomon, Loic Roux, B. Godinho, Sarah M Davis, D. V. Morrissey, Phillip, D. Zamore, S. A. Karumanchi, M. Moore, N. Aronin, A. Khvorova   +19 more
semanticscholar   +1 more source