Frontiers in Pharmacology, 2023 The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopoietic cell).
Guofang Shen +7 more
doaj +2 more sources
Lupus Science and Medicine, 2022 Objective The effectiveness and safety of sirolimus for SLE treatment have been shown in some uncontrolled studies. However, a comparison of sirolimus with other classic immunosuppressants has not been reported.
Xiaofeng Zeng +15 more
doaj +2 more sources
Sirolimus for the treatment of Graves’ orbitopathy [PDF]
Thyroid ResearchObjectives A role of mTOR (mammalian target of rapamycin) in the pathogenesis of Graves’ Orbitopathy (GO) has been proposed and rapamycin, better known as sirolimus, an mTOR inhibitor, was recently used in patients with GO.
Simone Comi +4 more
doaj +2 more sources
Prospective study of safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine in tuberous sclerosis complex children on sirolimus [PDF]
Human Vaccines & ImmunotherapeuticsWhile sirolimus is widely used in tuberous sclerosis complex (TSC), its impact on coronavirus disease 2019 (COVID-19) vaccination remains unclear. To evaluate the safety, immunogenicity, and efficacy of inactivated COVID-19 vaccine on the children with ...
Sufang Lin +10 more
doaj +2 more sources
A Tablet Matrix with Hibiscus rosa Sinensis Leave Mucilage for Effective Treatment of Rare Lymphangioleiomyomatosis Using Sirolimus [PDF]
Trends in Pharmaceutical Sciences, 2022 Using a blend of herbal and synthetic polymers, the authors aim to extend the release of Sirolimus from the tablets. Sirolimus was used as a model drug, Hydroxy Propyl Methyl Cellulose was used as a synthetic polymer, and mucilage from Hibiscus rosa ...
Hindustan Abdul Ahad +5 more
doaj +1 more source
Safety and Immunogenicity of Vaccines in Children with Kaposiform Hemangioendothelioma Receiving Sirolimus: A Prospective Study. [PDF]
Vaccines (Basel)Yuan J +7 more
europepmc +3 more sources
Interactions Between Sirolimus and Anti-Inflammatory Drugs: Competitive Binding for Human Serum Albumin [PDF]
Advanced Pharmaceutical Bulletin, 2016 Purpose: The aim of the present study was investigating the effects of three anti-inflammatory drugs, on Sirolimus protein biding. The binding site of Sirolimus on human serum albumin (HSA) was also determined.
Arash Khodaei +4 more
doaj +1 more source
Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters. [PDF]
PLoS ONE, 2012 The vast majority of glomerular filtrated phosphate is reabsorbed in the proximal tubule. Posttransplant phosphaturia is common and aggravated by sirolimus immunosuppression. The cause of sirolimus induced phosphaturia however remains elusive.
Maria Haller +10 more
doaj +1 more source
Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]
, 2016 Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S. +17 more
core +5 more sources
Journal of Research in Medical Sciences, 2023 Background: Sirolimus is a potent immunosuppressive in renal transplantation. However, its use is limited by some reported side effects. The objective of this study was to determine the side effect profile of sirolimus in renal transplant patients ...
Shahrzad Shahidi +3 more
doaj +1 more source