Results 41 to 50 of about 62,260 (164)

Sirolimus based immunosuppression is associated with need for early repeat therapeutic ERCP in liver transplant patients with anastomotic biliary stricture

Annals of Hepatology, 2013
Introduction. Sirolimus has inhibitory effects on epithelial healing and cholangiocyte regeneration. In liver transplantation (LT) patients, these effects may be greatest at the biliary anastomosis.
James H. Tabibian, M.D., Mohit Girotra, Hsin-Chieh Yeh, Dorry L. Segev, Murat T. Gulsen, Guldane Cengiz-Seval, Vikesh K. Singh, Andrew M. Cameron, Ahmet Gurakar   +8 more
doaj   +1 more source

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, EarlyView.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

Functional improvements in patients with lymphangioleiomyomatosis after sirolimus: an observational study

Orphanet Journal of Rare Diseases, 2018
Background Sirolimus has been shown to be effective in patients with lymphangioleiomyomatosis (LAM). We wish to summarize our experience using sirolimus and its effectiveness in LAM patients.
Yongzhong Zhan, Lisha Shen, Wenshuai Xu, Xiuxiu Wu, Weihong Zhang, Jun Wang, Xue Li, Yanli Yang, Xinlun Tian, Kai-Feng Xu   +9 more
doaj   +1 more source

Sirolimus Monotherapy for Thrombocytopenia in Primary Antiphospholipid Syndrome: A Pilot Study From a Tertiary Referral Center

Frontiers in Immunology, 2022
BackgroundThrombocytopenia (TP) is considered as a warning sign of high-risk antiphospholipid syndrome (APS) and sometimes a paradoxical sign of anti-thrombosis treatment.
Wenhui Xie, Lanlan Ji, Zhuoli Zhang
doaj   +1 more source

Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens

Clinical and Translational Science
Dose optimization of sirolimus may further improve outcomes in allogeneic hematopoietic cell transplant (HCT) patients receiving post‐transplantation cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD).
Ezhilpavai Mohanan, Guofang Shen, Suping Ren, Hsuan‐Hao Fan, Kao Tang Ying Moua, Aleksandra Karolak, Russell C. Rockne, Ryotaro Nakamura, David A. Horne, Christopher G. Kanakry, Donald E. Mager, Jeannine S. McCune   +11 more
doaj   +1 more source

Diagnosis and Management of Isolated Laryngeal Sarcoidosis: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective This study reviews the existing literature on patients diagnosed with sarcoidosis isolated to the larynx to improve our understanding of the diagnosis and management of this rare condition. Data Sources Embase, PubMed, Web of Science.
Raj Malhotra, Joseph Celidonio, Nicholas Hamilton, Alexandra Filipkowski, Kenneth Yan, Rachel Kaye   +5 more
wiley   +1 more source

Low-Dose Sirolimus Immunoregulation Therapy in Patients with Active Rheumatoid Arthritis: A 24-Week Follow-Up of the Randomized, Open-Label, Parallel-Controlled Trial

Journal of Immunology Research, 2019
Background. We have reported previously the insufficient absolute number or functional defects of regulatory T cells (Tregs) in patients with rheumatoid arthritis (RA), challenging conventional unspecific immunosuppressive therapy.
Hong-Yan Wen, Jia Wang, Sheng-Xiao Zhang, Jing Luo, Xiang-Cong Zhao, Chen Zhang, Cai-Hong Wang, Fang-Yuan Hu, Xiao-Juan Zheng, Ting Cheng, Hong-Qing Niu, Guang-Ying Liu, Wen-Xian Yang, Na-Na Yu, Jin-Li Ru, Qi-Xiang Chen, Xue-Chun Lu, Pei-Feng He, Chong Gao, Xiao-Feng Li   +19 more
doaj   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: a case report

BMC Nephrology
Renal impairment and rhabdomyolysis are rare in transplant patients receiving sirolimus. We report the case of a 54-year-old male who underwent liver transplantation and was initially treated with tacrolimus, mycophenolate mofetil, and glucocorticoids ...
Chang Gao, Zhi-Yu Chen, Liang Ma, Shen-Ju Gou   +3 more
doaj   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source