Results 41 to 50 of about 82,161 (336)

Ovarian Toxicity from Sirolimus [PDF]

New England Journal of Medicine, 2012
Low-dose oral sirolimus appears to increase the risk of menstrual-cycle disturbances and ovarian cysts. Monitoring patients for sirolimus-associated ovarian toxicity may be considered.
Braun Matthias, Young James, Reiner Cäcilia S, Poster Diane, Wüthrich Rudolf P, Serra Andreas L   +5 more
openaire   +3 more sources

Liquid chromatography-tandem mass spectrometry - Application in the clinical laboratory [PDF]

, 2003
This review provides a concise survey of liquid chromatography tandem mass spectrometry (LCTMS) as an emerging technology in clinical chemistry. The combination of two mass spectrometers with an interposed collision cell characterizes LCTMS as an ...
Ford RE, Kushnir MM, Kushnir MM, Muck W, Murdter TE, Rashed MS, Streit F, Taylor RL   +7 more
core   +1 more source

Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies

Pediatrics, 2016
BACKGROUND AND OBJECTIVES: Complicated vascular anomalies have limited therapeutic options and cause significant morbidity and mortality. This Phase II trial enrolled patients with complicated vascular anomalies to determine the efficacy and safety of ...
D. Adams, C. Trenor, A. Hammill, A. Vinks, Manish N. Patel, G. Chaudry, Mary Sue Wentzel, P. Mobberley-Schuman, L. Campbell, C. Brookbank, Anita Gupta, C. Chute, Jennifer Eile, J. McKenna, A. Merrow, Lin Fei, L. Hornung, M. Seid, A. Dasgupta, Belinda H. Dickie, R. Elluru, A. Lucky, B. Weiss, R. Azizkhan   +23 more
semanticscholar   +1 more source

Pharmacokinetic analysis after implantation of everolimus-eluting self-expanding stents in the peripheral vasculature [PDF]

, 2012
Background: A novel self-expanding drug-eluting stent was designed to release everolimus 225 mu g/cm(2) to prevent restenosis following peripheral arterial intervention.
Hausegger, Klaus A, Koppensteiner, Renate, Lammer, Johannes, Mellon, Rajeev M, Scheinert, Dierk, Schroë, Herman, Schwartz, Lewis B, Vermassen, Frank   +7 more
core   +2 more sources

Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma

Frontiers in Pharmacology, 2021
Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12–16.39 years of age) examines the effects of underlying factors on sirolimus concentrations through application of a ...
Xiao Chen, Dongdong Wang, Guangfei Wang, Yidie Huang, Xin Yu, Jinmiao Lu, Xiaowen Zhai, Hong Xu, Zhiping Li   +8 more
doaj   +1 more source

Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

Sarcoma, 2020
Purpose Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage in a genetically engineered MPNST ...
AeRang Kim, Yao Lu, S. Okuno, D. Reinke, Ophélia Maertens, J. Perentesis, M. Basu, P. Wolters, Thomas De Raedt, S. Chawla, R. Chugh, B. V. Van Tine, Geraldine O'Sullivan, A. Chen, K. Cichowski, B. Widemann   +15 more
semanticscholar   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents.

New England Journal of Medicine, 2007
BACKGROUND The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis, myocardial infarction, and death.
G. Stone, J. Moses, S. Ellis, J. Schofer, K. Dawkins, M. Morice, A. Colombo, E. Schampaert, E. Grube, A. Kirtane, D. Cutlip, M. Fahy, S. Pocock, R. Mehran, M. Leon   +14 more
semanticscholar   +1 more source

Implantation of paclitaxel-eluting stents in saphenous vein grafts: clinical and angiographic follow-up results from a multicentre study. [PDF]

, 2006
Objective: To define the clinical and angiographic follow-up results after implantation of paclitaxel-eluting stents (PESs) in stenotic saphenous vein grafts (SVGs). Design: Prospective multicentre study. Comparison with a control group.
Blindt, Ruediger, Boeckstegers, Peter, Heitzer, Thomas, Hoffmann, Rainer, Köster, Ralf, Pohl, Tilmann   +5 more
core   +2 more sources

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source