Results 71 to 80 of about 62,260 (164)

The Economic Consequences of Sirolimus Treatment in Patients With Vascular Malformations

Journal of Vascular Anomalies
Objectives:. Sirolimus is one of the first oral drugs for safe and effective treatment of patients with vascular malformations, and may save (expensive) interventions.
Veroniek E. M. Harbers, Wietske Kievit, Raquel Duque Jimenez, Leo J. Schultze Kool, Ingrid M. P. van Rijnsoever, Bas H. Verhoeven, Carine J. M. van der Vleuten, D. Maroeska W. M. te Loo, Members of the Vascular Anomalies Working Group (VASCA WG) of the European Reference Network for Rare Multisystemic Vascular Diseases (VASCERN)—Project ID: 769036   +8 more
doaj   +1 more source

Adalimumab‐responsive Monogenic Inflammatory Bowel Disease With Pseudopolyposis Characteristic of TGFBR2 Variant in Loeys‐Dietz Syndrome

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder caused by pathogenic variants in TGFBR1 or TGFBR2. It is characterized by vascular fragility, skeletal abnormalities, and predisposition to allergic and inflammatory conditions, including monogenic inflammatory bowel disease (IBD).
Tomomitsu Sado, Satoshi Ukai, Shingo Kurasawa, Yosuke Kono, Norio Hasuda, Mai Iwaya, Takaya Nakane, Tomomi Yamaguchi, Tomoki Kosho, Yoshiko Nakayama   +9 more
wiley   +1 more source

The patient perspective on sirolimus for epithelioid hemangioendothelioma (EHE): results of a community survey highlighting the importance of equitable access to treatments

Frontiers in Oncology
BackgroundEpithelioid hemangioendothelioma (EHE) is an ultra-rare, vascular sarcoma with clinical presentation ranging from an indolent to an aggressive form.
Denise Robinson, Hugh Leonard, Giacomo Giulio Baldi, William D. Tap, Robin L. Jones, Silvia Stacchiotti, Pan Pantziarka, Pan Pantziarka   +7 more
doaj   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background A significant proportion of patients presenting a primary sclerosing cholangitis (PSC) will require liver transplantation (LT). The present study aimed to investigate graft loss and patient death in a large cohort of patients. Methods We conducted a nationwide multicenter retrospective study including all adult patients transplanted
Florian Veyre, Claire Francoz, Domitille Erard, Eleonora DeMartin, Laure Elkrief, Camille Besch, Olivier Boillot, Filomena Conti, Sébastien Dharancy, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie‐Noëlle Hilleret, Vincent Leroy, Isabelle Ollivier‐Hourmand, Marilyne Gratien, Pauline Houssel‐Debry, Nassim Kamar, Olivier Roux, Jean‐Baptiste Hiriart, Marie Irles‐Depe, Sophie Pellegrin, François Durand, Georges‐Philippe Pageaux, Stéphanie Faure, Audrey Coilly, Sylvie Radenne, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marianne Latournerie, Karim Boudjema, Ephrem Salamé, Olivier Chazouillères, Christophe Corpechot, Jérôme Dumortier   +35 more
wiley   +1 more source

Long-term efficacy and safety of sirolimus therapy in patients with lymphangioleiomyomatosis

Orphanet Journal of Rare Diseases, 2019
Background Sirolimus has been confirmed to be effective for lymphangioleiomyomatosis (LAM), a rare multisystem neoplastic disease in women. The long-term effects of sirolimus treatment for LAM, however, are largely unknown.
Siqi Hu, Xiuxiu Wu, Wenshuai Xu, Xinlun Tian, Yanli Yang, Shao-Ting Wang, Song Liu, Xingxiang Xu, Kai-Feng Xu   +8 more
doaj   +1 more source

Early Prediction of Hepatic Decompensation in Cirrhosis Using Optimised XGBoost Models at the Initial Outpatient Hepatology Visit

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background and Aims Hepatic decompensation represents a critical transition in cirrhosis, leading to increased morbidity, mortality and healthcare utilisation. Identifying patients at risk of decompensation remains a clinical challenge. We aimed to develop and validate XGBoost models to predict hepatic decompensation at multiple time points ...
Micah Grubert Van Iderstine, Sem Perez, Gregory S. Jackson, Tyler Szun, Caelan Stephanson, Megan Weisshaar, Gerald Y. Minuk, Nabiha Faisal   +7 more
wiley   +1 more source

Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report

Pharmacology Research & Perspectives
Individual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food.
Camilo Scherkl, Andreas D. Meid, Sven E. Cuntz, Laura Classen, Johanna Weiss, David Czock, Walter E. Haefeli   +6 more
doaj   +1 more source

Gamma Irradiation of Poly(lactide‐co‐glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates

Biotechnology and Bioengineering, Volume 123, Issue 3, Page 742-751, March 2026.
ABSTRACT Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood‐mediated inflammatory response. Herein, we investigated the design of microporous poly(D,l‐lactide‐co‐glycolide) (PLG) scaffolds for extrahepatic islet ...
Jessica L. King, Christopher Spencer, Richard Youngblood, Kelly Crumley, Elizabeth Bealer, Peter D. Rios, Ira Joshi, Sofia Ghani, Douglas Isa, James J. McGarrigle, David Cook, Conor Locke, Adam Abraham, Andrea Clark, José Oberholzer, Lonnie D. Shea   +15 more
wiley   +1 more source

Lung Transplantation Outcomes and Peritransplant Sirolimus Use in Lymphangioleiomyomatosis

Annals of Thoracic Surgery Short Reports
Background: With the introduction of sirolimus as medical therapy for lymphangioleiomyomatosis (LAM), an updated evaluation of LAM lung transplant (LT) outcomes and characterization of peritransplant sirolimus use is needed.
Emily L. Larson, BS, Reed T. Jenkins, BA, Jessica M. Ruck, MD, Laura B. Zeiser, MS, Alice L. Zhou, MS, Alfred J. Casillan, MD, PhD, Dorry L. Segev, MD, Allan B. Massie, MD, Jinny S. Ha, MD, Pali D. Shah, MD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD   +11 more
doaj   +1 more source