Investigating the Combined Effect of Aerobic Training with Resveratrol Resveratrol Consumption on SIRT1 and PGC-1α Levels in Gastrocnemius Muscle of Rats after Spinal Cord Injury [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Atrophy of the skeletal system caused by spinal cord injury (SCI) can cause secondary systemic metabolic dysfunction, such as glucose intolerance, type 2 diabetes, and insulin resistance.
Eskandar Garmei +2 more
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Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]
, 2018 The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
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Journal of Integrative NeuroscienceIntroduction: The effects of remimazolam (Re) in combination with andrographolide (AP) on learning, memory, and motor abilities in rats following cardiopulmonary bypass (CPB) surgery were studied.
Chong Chen, Lixia Lan, Kai Xu
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The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Biomolecules, 2020 Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas +2 more
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Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
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结直肠肛门外科[Objectives] To preliminarily investigate the mechanism of Buzhong Yiqi decoction in inhibiting endothelial cell pyroptosis via SIRT1. [Methods] A hemorrhoid model was established in SD rats by topical application of glacial acetic acid. Thirty rats were
Xiao Kaihua +4 more
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Effect of H2S on the circadian rhythm of mouse hepatocytes
Lipids in Health and Disease, 2012 Background Dysregulation of circadian rhythms can contribute to diseases of lipid metabolism. NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on ...
Shang Zhanxian +4 more
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Frontiers in GeneticsAging is linked to a time-associated decline in both cellular function and repair capacity leading to malfunction on an organismal level, increased frailty, higher incidence of diseases, and death. As the population grows older, there is a need to reveal mechanisms associated with aging that could spearhead treatments to postpone the onset of age ...
Blanka Rogina +2 more
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SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress [PDF]
, 2014 SIRT1, an NAD-dependent deacetylase, plays a role in regulation of autophagy. SIRT1 increases mitochondrial function and reduces oxidative stress, and has been linked to age-related reactive oxygen species (ROS) generation, which is highly dependent on ...
Broxmeyer, Hal E. +4 more
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Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]
, 2019 Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen +7 more
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