Results 231 to 240 of about 72,220 (305)

Serum α-Klotho and SIRT1 - Relationship with graft function, inflammation and hospitalization rates in kidney transplant recipients. [PDF]

Transpl Int
Sączek A, Batko K, Banaszkiewicz M, Małyszko J, Koc-Żórawska E, Żórawski M, Małyszko J, Niezabitowska K, Sobczyńska K, Miarka P, Bętkowska-Prokop A, Krzanowska K, Krzanowski M.   +12 more
europepmc   +1 more source

SIRT1 Gene [PDF]

, 2020
openaire   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL-Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development. [PDF]

Aging Cell
Li Y, Wu J, Liu R, Li Q, Xue F.
europepmc   +1 more source

Nano‐Rosmarinic Acid Protects Against Chlorfenapyr‐Induced Testicular Toxicity Through Modulation of NRF2/HO‐1 and NF‐κB/NLRP3 Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Chlorfenapyr reduces testicular weight, sperm quality, and reproductive hormones. This study highlights that RA within chitosan nanoparticles (RA‐CHNPs) are superior to Rosmarinic acid in mitigating CFP‐induced testicular damage. RA within chitosan nanoparticles leads to the reduction of NF‐κB and NLRP3 expression in seminiferous tubules and activates ...
Ahmad Najem Alshammari, Ayat B. Al‐Ghafari, Huda A. Al Doghaither, Ahmed M. S. Hegazy, Ekramy M. Elmorsy, Asmaa Fady Sharif, Zahraa Khalifa Sobh   +6 more
wiley   +1 more source

Bmal1 Attenuates Collagen-Induced Arthritis by Regulating Macrophage Polarization via Sirt1. [PDF]

J Inflamm Res
Ye L, Wang X, Xu W, Wu H.
europepmc   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Resveratrol Alleviates Arsenic-Induced Liver Fibrosis in Rats by Correcting SIRT1-Mediated Disorder of Hepatic Bile Acid Metabolism. [PDF]

Int J Mol Sci
Wang Q, Chen H, Ran Q, Hu F, Fu Q, Ma L.
europepmc   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source