Results 251 to 260 of about 102,380 (310)

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells. [PDF]

J Inflamm Res
He F, Liu C, Yu Y, Wang Q, Li L, Chao X, Chen L, Yu C.   +7 more
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway. [PDF]

Pharm Biol
Wu Y, Fan L, You H, Lu Y, Lin M.
europepmc   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3480-3490, May 2026.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD. [PDF]

Brain
Lagartos-Donate MJ, Escobar-Doncel B, Zhang SQ, Pan JP, Villaseca González N, Anisimov A, Montaldo NP, Jensen V, Mao L, Li B, Banzon-Pereira N, Shi L, Cao SQ, Caponio D, Wang P, Nair RR, Luo OJ, Chen G, Nevado-Holgado AJ, Buckley N, Nilsen HL, Fang EF.   +21 more
europepmc   +1 more source

Treating mitochondrial myopathy : can we boost oxidative phosphorylation activities by enhancing mitochondrial biogenesis? [PDF]

, 2014
De Paepe, Boel
core  

FNDC4 and FNDC5 Attenuate SARS‐CoV‐2 S1‐Induced Inflammatory Responses in Human Adipose Tissue

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
In obesity, reduced FNDC4 and FNDC5 amplify SARS‐CoV‐2 S1–driven inflammation in visceral adipose tissue. These adipo‐myokines limit adipocyte–macrophage inflammatory signalling, suggesting a protective role against viral‐induced adipose tissue dysfunction.
Gabriela Neira, Julia Hernández‐Castañeda, Victoria Catalán, Sara Becerril, Marina Martín, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Gómez‐Ambrosi, Javier Escalada, Gema Frühbeck, Amaia Rodríguez   +11 more
wiley   +1 more source

NMN/NAD⁺/SIRT1 axis activates NAMPT to ameliorate H₂O₂-triggered the impairment of progesterone synthesis in ovarian granulosa cells. [PDF]

J Ovarian Res
Wang Y, Li Q, Li Y, Ma Z, Xu H, Chen K, Li J, Lan D, Fu W.   +8 more
europepmc   +1 more source

Hydroxytyrosol Mitigates Anxiety‐Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Hydroxytyrosol (HTyr), a phenolic compound of olive oil, exerts beneficial effects on several age‐related diseases. We previously demonstrated that oral HTyr administration in aging mice enhances hippocampal neurogenesis, known to play a role in memory formation and emotional behaviors. In the present study, we found that HTyr preferentially stimulates
Giorgio D'Andrea, Laura Bertini, Marco Costanzi, Fabiana Canini, Roberta Bernini, Andrea Fochetti, Mariangela Clemente, Silvia Proietti, Manuela Ceccarelli, Carla Caruso, Maurizia Caruso, Ferdinando Scavizzi, Marcello Raspa, Felice Tirone, Laura Micheli   +14 more
wiley   +1 more source

Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation. [PDF]

Neurotherapeutics
Lin L, Li L, Ren S, Liu L, Liu Y, Zhang W, Gao Z, Ni X, Li H, Duan X, Tao S, Zhao T, Hai X.   +12 more
europepmc   +1 more source