Results 261 to 270 of about 77,206 (307)
<i>SIRT1</i> rs2394445 associates with serum triacylglycerol lipidomic profile in metabolic dysfunction-associated steatotic liver disease. [PDF]
Front NutrPan Q +7 more
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ROS-ATM-CBP axis-mediated PARP1 lactylation aggravates doxorubicin-induced cardiotoxicity. [PDF]
Clin Transl MedWang W, Sun Y.
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[Expression of Concern] Obesity accelerates murine gastric cancer growth by modulating the Sirt1/YAP pathway. [PDF]
Oncol LettLi HJ +5 more
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Sanzi Sijun Formula Alleviates Lipotoxic Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/SIRT1 Signaling Pathway. [PDF]
Pharmaceuticals (Basel)Ding J +8 more
europepmc +1 more source
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Nihon rinsho. Japanese journal of clinical medicine, 2016
Silent information regulator 2 homolog 1 (SIRT1), a product of the so called "longevity gene", is a protein deacetylase that has been reported to suppress cardiovascular pathologies such as myocardial infarction, and neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease via anti-apoptosis, anti ...
Yorito, Hattori, Masafumi, Ihara
openaire +3 more sources
Silent information regulator 2 homolog 1 (SIRT1), a product of the so called "longevity gene", is a protein deacetylase that has been reported to suppress cardiovascular pathologies such as myocardial infarction, and neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease via anti-apoptosis, anti ...
Yorito, Hattori, Masafumi, Ihara
openaire +3 more sources
Metabolic benefits from Sirt1 and Sirt1 activators
Current Opinion in Clinical Nutrition and Metabolic Care, 2009To evaluate the role of mammalian Sirt1 and Sirt1 activators in the protection from metabolic disorders such as diet-induced obesity, diabetes type 2, or nonalcoholic fatty liver disease.Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that are activated by NAD+ and inhibited by NAD in its reduced form (NADH)
Nilika, Chaudhary, Paul T, Pfluger
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Molecular Aspects of Medicine, 2008
SIRT1 is the mammalian homologue of yeast silent information regulator (Sir)-2, a member of the sirtuin family of protein deacetylases which have gained much attention as mediators of lifespan extension in several model organisms. Induction of SIRT1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and ...
Bor Luen, Tang, Christelle En Lin, Chua
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SIRT1 is the mammalian homologue of yeast silent information regulator (Sir)-2, a member of the sirtuin family of protein deacetylases which have gained much attention as mediators of lifespan extension in several model organisms. Induction of SIRT1 expression also attenuates neuronal degeneration and death in animal models of Alzheimer's disease and ...
Bor Luen, Tang, Christelle En Lin, Chua
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Bioorganic & Medicinal Chemistry Letters, 2017
In the current study, bivalent compounds 1-17 constructed by covalently linking the ɛ-amino group of lysine in a tripeptidic scaffold to a functionality via a linker were prepared and examined for their inhibitory potencies against SIRT1, a prototypical member of the β-nicotinamide adenine dinucleotide (β-NAD+)-dependent sirtuin family of protein Nε ...
Juan, Wang +3 more
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In the current study, bivalent compounds 1-17 constructed by covalently linking the ɛ-amino group of lysine in a tripeptidic scaffold to a functionality via a linker were prepared and examined for their inhibitory potencies against SIRT1, a prototypical member of the β-nicotinamide adenine dinucleotide (β-NAD+)-dependent sirtuin family of protein Nε ...
Juan, Wang +3 more
openaire +2 more sources