Results 261 to 270 of about 102,380 (310)

The PPARβ/Delta‐Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre‐Clinical Model of Acute Lung Inflammation

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Activation of PPARβδ via chemical agonists or free fatty acids lead to the increased production of ANGPTL4 by human bone marrow (BM)‐MSCs. MSC‐conditioned medium (CM) derived ANGPTL4 promotes wound healing in lung epithelial cells in vitro, enhances endothelial barrier function in vivo and reduced pro‐inflammatory cytokine release in a pre‐clinical ...
Courteney Tunstead, Molly Dunlop, Sinéad Ryan, Evelina Volkova, Evangeline Johnston, Sabrina Batah, Claudia C. Dos Santos, Bairbre McNicholas, Claire Masterson, John G. Laffey, Karen English   +10 more
wiley   +1 more source

SIRT1-mediated FABP4 destabilization attenuates fibrosis and ferroptosis in non-alcoholic fatty liver disease. [PDF]

Clin Exp Med
Qiu H, Chen K, Qiu Y, Yang Y, Wang T, Wang W, Jiang L.   +6 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

<i>Sechium edule</i> var. <i>nigrum spinosum</i> (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus. [PDF]

Molecules
Gavia-García G, Hernández-Álvarez D, Arista-Ugalde TL, Aguiñiga-Sánchez I, Santiago-Osorio E, Cadena-Iñiguez J, Rosado-Pérez J, Mendoza-Núñez VM.   +7 more
europepmc   +1 more source

Caspase‐6 Controls Lipid and Energy Metabolism in Diet‐Induced Obesity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This study reveals an unknown metabolic role of caspase‐6 beyond cell death. Caspase‐6 deficiency protects against HFD‐induced obesity by increasing energy expenditure, reducing inflammation, and improving glucose metabolism. Mechanistically, caspase‐6 cleaves PPARγ and SP1 to suppress ATGL expression.
Abhishek Gupta, Wenjing You, Linmeng Han, Jianfei Ji, Meixia Pan, Xianlin Han, Xiaoli Sun, Peng Zhao   +7 more
wiley   +1 more source

Targeting the SIRT1-NAT10-GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane-Induced Cognitive Impairment in Aging. [PDF]

CNS Neurosci Ther
Xie X, Du W, Zhang Y, Zhang X.
europepmc   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

A cascade via CD276/PI3K/SIRT1/E-Cad in overcoming contact inhibition of proliferation in hepatocellular carcinoma cells. [PDF]

Mol Clin Oncol
Yu X, Su R, Cao G, Xie H, Zhou L, Zheng S.   +5 more
europepmc   +1 more source