Results 241 to 250 of about 72,220 (305)

Berbamine sensitizes hepatocellular carcinoma to chemotherapy by inhibiting autophagy <i>via</i> modulating SIRT1-mediated acetylation. [PDF]

Front Pharmacol
Peng Q, Xiao L, Huang X, Huang Z, Zhang G, Zhou J, Tan Y.   +6 more
europepmc   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Sirtuin 1 is a key molecular link between cellular senescence and heart failure. [PDF]

Front Mol Med
Krekora J, Drożdż J, Blasiak J.
europepmc   +1 more source

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer. [PDF]

J Exp Med
Nunes de Almeida F, Vasciaveo A, Giacobbe A, Di Bernardo M, Zou M, Antao AM, de Brot S, Rodriguez-Calero A, Chui A, Wang ALE, Floc'h N, Kim JY, Park S, Afari SN, Mukhammadov T, Ortega N, Josyula SS, Arriaga JM, Wang J, Lu J, Shen MM, Rubin MA, Califano A, Abate-Shen C.   +23 more
europepmc   +1 more source

Mechanistic Study of Platelet Membrane‐Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation

Aging Cell, Volume 25, Issue 8, August 2026.
Schematic diagram of the mechanism by which PM@RSV NPs alleviate AS via FOXM1 activation. ABSTRACT Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti‐inflammatory, and pro‐angiogenic effects, but its clinical use is restricted by
Li Xiao, Zexin Zhan, Ping Liu, Bing Qin
wiley   +1 more source

Discriminative Ability and Clinical Associations of Serum SIRT1, SIRT3, Apelin, and ELA in Patients with Diabetic Foot Infection. [PDF]

Life (Basel)
Canpolat-Erkan RE, Tekin R, Ekinci A, Aşır F.   +3 more
europepmc   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Cordycepin Ameliorates Constant Light-Induced Thermogenic Dysfunction in Brown Adipose Tissue by Activating SIRT1-Mediated Mitochondrial Homeostasis. [PDF]

Int J Mol Sci
Bi Y, Zhang G, Wang Y, Zhang L, Wu S, Zhang Y, Li X, Yang D.   +7 more
europepmc   +1 more source

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC‐1α Signaling Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng, Han Ding, Ziye Li, Qian Wang, Peiyao Guan, Tingting Wang, Jiayun Wang, Yansong Fu, Lizhang Chen, Hong Qin   +9 more
wiley   +1 more source

Calculus Bovis ameliorates primary sclerosing cholangitis via a dual-pronged mechanism restoring bile acid and lipid homeostasis in the gut-liver axis. [PDF]

Chin Med
Gong X, Chen Y, Zhao T, Li N, Yang G, Qiu L, Yu Z, Liu D, Xiang D.   +8 more
europepmc   +1 more source