Results 241 to 250 of about 102,380 (310)

Ginsenoside Rb2 improves diminished ovarian reserve through regulation of gonadal hormones and apoptosis via SIRT1. [PDF]

J Ovarian Res
Zhu C, Yi M, Cao H, Li H, Tang H, Xu L, Li L.   +6 more
europepmc   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima, Keisuke Yaku, Shotaro Kosugi, Ryunosuke Mitsuno, Kenji Kaneko, Yoshinaga Kawano, Akihito Hishikawa, Seiya Mizuno, Manami Katoh, Akiko Satoh, Shinya Toyokuni, Tatsuhiko Azegami, Kenichiro Kinouchi, Shintaro Yamaguchi, Hiroshi Itoh, Takeshi Kanda, Toshimasa Yamauchi, Takashi Nakagawa, Kaori Hayashi, Jun Yoshino   +19 more
wiley   +1 more source

Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder. [PDF]

Nat Sci Sleep
Liu GX, Zhang Y, Song Y, Yang S, Su AX, Feng YZ, Zhou YS, Ma ZJ, Xia L, Chen GH.   +9 more
europepmc   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Anti-inflammatory effects of oridonin on an <i>in vitro</i> model using LPS-treated human intestinal Caco-2 cells. [PDF]

Exp Ther Med
Wang M, Xu B, Li L, Wang Y, Li M.
europepmc   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review). [PDF]

Int J Mol Med
Xiang JN, Zhou CY, Zhao YD, Xu X, Ling SB.   +4 more
europepmc   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promoting SIRT1/SIRT3/FOXO3a-Dependent Mitochondrial Quality Control. [PDF]

Antioxidants (Basel)
Gao L, Shen J, Gao J, Li T, Yan D, Zeng X, Meng J, Li H, Chen D, Wu J.   +9 more
europepmc   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, Volume 183, Issue 10, Page 2592-2612, May 2026.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source