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Current Pharmaceutical Design, 2009
The intersection between regulatory pathways responsive to metabolic fluctuation on one hand, and to cellular stress on the other, is a fascinating area within which NAD/NADH responsive proteins play a major role [1, 2]. A key player amongst these is SIRT1, a member of the mammalian sirtuin family (SIRT1-7).
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The intersection between regulatory pathways responsive to metabolic fluctuation on one hand, and to cellular stress on the other, is a fascinating area within which NAD/NADH responsive proteins play a major role [1, 2]. A key player amongst these is SIRT1, a member of the mammalian sirtuin family (SIRT1-7).
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DJ-1 activates SIRT1 through its direct binding to SIRT1
Biochemical and Biophysical Research Communications, 2016The DJ-1 gene is a ras-dependent oncogene and also a causative gene for a familial form of Parkinson's disease park7. DJ-1 is a multi-functional protein and plays roles in regulation of cell growth, cells death, metabolism and mitochondrial homeostasis against oxidative stress.
Kazuko, Takahashi-Niki +6 more
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Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
Redox Biology, 2022Junlian Gu, Mengjie Xiao, Yufeng Tang
exaly
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Experimental and Molecular Medicine, 2007Jaemin Jeong, Kyung-Mi Lee, Bon-Hong Min
exaly
C/EBPα regulates SIRT1 expression during adipogenesis
Cell Research, 2010Qiwei Zhai, Xinjian Ge
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SIRT1 transgenic mice show phenotypes resembling calorie restriction
Aging Cell, 2007Jianyuan Luo +2 more
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SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.
European Heart Journal, 2010Sokrates Stein, Burkhard Becher
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