Structure-Guided Optimization and Biological Validation of 1,3,4-Thiadiazole-Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions. [PDF]
Drug Dev ResABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Aksel AB +9 more
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Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning [PDF]
Discover OncologyBackground Hepatocellular carcinoma (HCC) is a prevalent global malignancy characterized by a high incidence and poor prognosis. Current diagnostic and therapeutic modalities are insufficient to meet the demands for effective HCC diagnosis and management.
Changan Chen +7 more
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Usnic acid reduces colon cancer cell viability and colony formation by aff ecting cancer cell metabolism [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Today, some natural and plant-based products are of great interest, at least as supplements, in cancer prevention and treatment due to their anti-cancer properties.
Turgut ANUK +7 more
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Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury
BMC Genomics, 2020 Background Chemotherapy-induced peripheral neuropathy is not only one of the most common causes of dose reduction or discontinuation of cancer treatment, but it can also permanently decrease the quality of life of cancer patients and survivors.
Xin Zhao +4 more
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SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. [PDF]
PLoS ONE, 2017 The sirtuin proteins are an evolutionarily conserved family of NAD+-dependent deacetylases that regulate various cellular functions. Among the seven sirtuins, SIRT2 is predominantly found in the cytoplasm, and is present in a wide range of tissues ...
Xiaomin Zhang, Gohar Azhar, Jeanne Y Wei
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Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction
Genetics Research, 2022 Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with
Changhui Zhu +8 more
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The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?
Frontiers in Oncology, 2020 Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase (HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a number of non-histone proteins and plays a pivotal role in various ...
Lin Zhang +6 more
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Expression and clinical significance of SIRT2 in urothelial bladder cancer and its impact on cancer cell proliferation, invasion and migration [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the expression and clinical significance of silent information regulator 2 (SIRT2) form tissue of urothelial bladder cancer(UBC) and the effects of down-regulation of SIRT2 on the proliferation, invasion and migration of bladder ...
JIN Xiaoxia, LU Xiaoyun, LIU Yushan, LIANG Lina
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Frontiers in Cellular Neuroscience, 2019 Sirtuin 2 (SIRT2) is thought to be important in the pathogenesis of Parkinson’s disease (PD), and the inhibition of SIRT2 rescues α-synuclein toxicity in a cellular model of PD.
Shuhu Liu +5 more
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Cancer Biology & Medicine, 2020 Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou +10 more
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