Results 121 to 130 of about 10,461 (217)
Lessons learned from a SIRT2-selective inhibitor
Oncotarget, 2016 Developing targeted cancer therapies typically starts with the identification of oncoproteins that are mutated or over-activated in tumors, followed by the development of small molecules that target the oncoproteins. A paradigm example is the development of Gleevec targeting the BCR-ABL oncoprotein in chronic myeloid leukemia.
Jing, Hui, Lin, Hening
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SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease [PDF]
Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases; however, its specific function remains controversial.
Aleixo, M. +17 more
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Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits our ability to provide targeted therapy interventions for HCC.
Fang Wang +10 more
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Protective Effects of SIRT2 Inhibition on Cardiac Fibrosis
The Anatolian Journal of CardiologyA primary factor in the pathogenesis of aging is oxidative stress, with cardiac inflammation and fibrosis being contributed to by increased oxidative stress as organisms age. Oxidative stress enhances the cardiac fibrotic signaling pathway, with reactive oxygen species inducing cardiac fibrosis through increased expression of the profibrotic factor ...
Akbulut, Muge +6 more
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SIRT2 counteracts primate cardiac aging
Nature Aging, 2023 Laura Cox, Michael Olivier
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Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression [PDF]
We previously reported that the suppression of SIRT2, an NAD + -dependent protein deacetylases, induces p53 accumulation via degradation of p300 and the subsequent MDM2 degradation, eventually leading to apoptosis in HeLa cells.
80305573 +13 more
core
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-BiologichePlant kingdom provides a wide plethora of remedies which can be exploited to treat prevent and manage human ailments, among which cancer. In these regards, there is consistent supporting evidence of the beneficial properties of Citrus fruits, which are ...
Alessandro Maugeri +3 more
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NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH
Scientific ReportsCuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang +9 more
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Computational Design and Optimization of Peptide Inhibitors for SIRT2
PharmaceuticalsSirtuin 2 (SIRT2), an NAD+-dependent deacetylase, is crucial for regulating vital physiological processes, including aging, DNA repair, and cell cycle progression. Its abnormal activity is linked to diseases such as Parkinson’s disease, cancer, and metabolic disorders, making it a potential target for therapeutic intervention.
Heba A. Alkhatabi +3 more
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