Results 121 to 130 of about 11,198 (208)

SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis

, 2018
Heart failure is an aging-associated disease that is the leading cause of death worldwide. Sirtuin family members have been largely studied in the context of aging and aging-associated diseases. Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of
Kondapalli, Mrudula S, Sarikhani, Mohsen, Ravi, Venkatraman, Sundaresan, Nagalingam Ravi, Pandit, Anwit S, Khan, Danish, Rao, Swathi, Kumar, Shweta, Tamta, Ankit K, Desingu, Perumal A, Inbaraj, Meena, Jain, Aditi, Maity, Sangeeta, Mishra, Sneha   +13 more
core   +1 more source

NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH

Scientific Reports
Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S) proteins, which are crucial for a wide range of important cellular functions, including DNA replication and damage repair. Sirt2 and sirt4 are lipoamidases that
Yingying Zhang, Shuting Qiu, Shihan Shao, Yuejia Cao, Yu Hong, Xianrong Xu, Xuexian Fang, Chunhong Di, Jun Yang, Xiaohua Tan   +9 more
doaj   +1 more source

SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease [PDF]

Sirtuin 2 (SIRT2) has been proposed to have a central role on aging, inflammation, cancer and neurodegenerative diseases; however, its specific function remains controversial.
Aleixo, M., Maioli, Silvia, Azqueta, Amaya, Sola-Sevilla, N., Eroli, F., Puerta, E., Mesa-Lombardo, A., Expósito, Sara, Martín, E. D., Ramírez, M. José, Tordera, R.M., Martín, E.D., Suzuki, T., Matton, A., Tordera, R. M., Diaz-Perdigón, T., Solas, Maite, Zamani, F.   +17 more
core   +1 more source

SIRT2 orchestrates the DNA damage response [PDF]

Cell Cycle, 2016
Hui, Zhang, PamelaSara E, Head, David S, Yu   +2 more
openaire   +2 more sources

Synthese und Charakterisierung von SIRT2-Inhibitoren als epigenetische Modulatoren [PDF]

, 2018
In dem Werk wird die Synthese von bisher unbekannten SIRT2-Inhibitoren mit 2-Naphthol- und partiell hydriertem Indolgrundkörpern beschrieben. Am Ende ist es gelungen potente und SIRT2-selektive Inhibitoren mit unterer mikromolarer Hemmkonzentration zu ...
Vojacek, Steffen
core  

Sirtuin 2 (SIRT2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

SIRT2 wt Allele [PDF]

, 2020
openaire   +1 more source

SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation. [PDF]

Proc Natl Acad Sci U S A
Hill KK, Barry AP, Reinoso-Vizcaino NM, Haynes LE, Bonglack EN, Ferreira DF, Miller SE, Hirschey MD, Chiang LW, Remiszewski S, Luftig MA.   +10 more
europepmc   +1 more source

The Role SIRT2 in Programmed Necrosis [PDF]

Neurosurgery, 2013
Robert M. Starke, Ricardo J. Komotar, E. Sander Connolly   +2 more
openaire   +1 more source

Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol. [PDF]

Front Pharmacol
Amegble K, Liu L, Duan T, Fang K, Petronek MS, Bailey CK.   +5 more
europepmc   +1 more source