Results 111 to 120 of about 11,198 (208)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-BiologichePlant kingdom provides a wide plethora of remedies which can be exploited to treat prevent and manage human ailments, among which cancer. In these regards, there is consistent supporting evidence of the beneficial properties of Citrus fruits, which are ...
Alessandro Maugeri +3 more
doaj +1 more source
The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation
The Journal of Clinical InvestigationSelective and controlled expansion of endogenous β cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β cell proliferation to avoid excessive β cell expansion.
Matthew Wortham +19 more
doaj +1 more source
Up-regulation of Sirt2 during mouse ESC differentiation.
, 2013 (A) Real-time PCR analysis of Sirt2 in EB differentiation. (B) The mRNA expression level of Sirt2 during RA-induced differentiation. (C) The mRNA expression levels of Sirt2, Sirt1, Sirt3 and self-renewal marker genes Oct4, Nanog and Rex1 in control ...
Wen Chen (30046) +6 more
core +1 more source
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits our ability to provide targeted therapy interventions for HCC.
Fang Wang +10 more
doaj +1 more source
SIRT2 counteracts primate cardiac aging
Nature Aging, 2023 Laura Cox, Michael Olivier
openaire +2 more sources
Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression [PDF]
We previously reported that the suppression of SIRT2, an NAD + -dependent protein deacetylases, induces p53 accumulation via degradation of p300 and the subsequent MDM2 degradation, eventually leading to apoptosis in HeLa cells.
80305573 +13 more
core +1 more source
Computational Design and Optimization of Peptide Inhibitors for SIRT2
PharmaceuticalsSirtuin 2 (SIRT2), an NAD+-dependent deacetylase, is crucial for regulating vital physiological processes, including aging, DNA repair, and cell cycle progression. Its abnormal activity is linked to diseases such as Parkinson’s disease, cancer, and metabolic disorders, making it a potential target for therapeutic intervention.
Heba A. Alkhatabi +3 more
openaire +3 more sources
Protective Effects of SIRT2 Inhibition on Cardiac Fibrosis
The Anatolian Journal of CardiologyA primary factor in the pathogenesis of aging is oxidative stress, with cardiac inflammation and fibrosis being contributed to by increased oxidative stress as organisms age. Oxidative stress enhances the cardiac fibrotic signaling pathway, with reactive oxygen species inducing cardiac fibrosis through increased expression of the profibrotic factor ...
Akbulut, Muge +6 more
openaire +3 more sources