Results 111 to 120 of about 10,461 (217)
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
The selectivity pocket is a key binding site for selective inhibitors of the NAD+-dependent lysine deacylase Sirtuin 2 (Sirt2), a promising drug target due to its involvement in diseases like cancer and neurodegeneration. This pocket typically opens only upon binding of long fatty-acylated substrates or selective inhibitors. While crystal soaking could
Florian Friedrich +7 more
openaire +1 more source
Up-regulation of Sirt2 during mouse ESC differentiation. [PDF]
, 2013 (A) Real-time PCR analysis of Sirt2 in EB differentiation. (B) The mRNA expression level of Sirt2 during RA-induced differentiation. (C) The mRNA expression levels of Sirt2, Sirt1, Sirt3 and self-renewal marker genes Oct4, Nanog and Rex1 in control ...
Wen Chen (30046) +6 more
core +1 more source
Frontiers in Molecular Neuroscience, 2018 Recently, emerging evidences show that sirtuins (SIRTs) modulate aging progress and affect neurodegenerative diseases. For example, inhibition of SIRT2 has been recognized to exert neuroprotective effects in Parkinson’s disease (PD).
Sifan Sun +10 more
doaj +1 more source
Insights Into the Susceptibility of Fungal Infection and STAT3 Genetic Mutations
Mycoses, Volume 69, Issue 7, July 2026.ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor that regulates a spectrum of genes and signalling pathways critical for the antifungal immune response. Mutations in the STAT3 gene confer susceptibility to severe and recurrent fungal infections, predominantly via disruption of interleukin‐17 (IL‐17 ...
Fengming Li +5 more
wiley +1 more source
Neuroprotective Effects of Sirt2 Inhibition In Aging
, 2018 Öz bulunamadı.
Aktan, Arzu Keskin +2 more
openaire +4 more sources
Neoplasia: An International Journal for Oncology Research, 2018 Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory
Yang Li +16 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in the pathology of Parkinson’s disease (PD). However, the association between potential functional polymorphisms in the SIRT2 gene and PD still needs to be identified.
Yan Wang +14 more
doaj +1 more source
MULTIPLE ENZYMATIC FUNCTIONS OF SIRT2 AND ITS INVOLVEMENT IN CANCER [PDF]
, 2017 SIRT2 belongs to the mammalian sirtuin or NAD-dependent lysine deacylase family. Growing evidence suggests that SIRT2 plays important roles in cell cycle regulation, stress response, metabolism and differentiation by deacetylating a wide variety of ...
Jing, Hui
core +1 more source
Journal of Translational MedicineNAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases.
Jingru Guo +11 more
doaj +1 more source