Results 101 to 110 of about 10,461 (217)
Aging Cell, Volume 25, Issue 8, August 2026.Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma +8 more
wiley +1 more source
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity [PDF]
, 2014 Resistance to targeted therapies is a major problem in cancer treatment. The epidermal growth factor receptor (EGFR) antibody drugs are effective in a subset of colorectal cancers, but the molecular mechanisms of resistance are understood poorly.
Bajpe, P.K. +13 more
core +1 more source
Factors Determining Sirtuin‐1 Target Engagement
Advanced Biology, Volume 10, Issue 7, July 2026.ABSTRACT Sirtuin‐1 (Sirt1) is a key NAD+‐dependent deacylase regulating metabolism, stress responses, genome stability, and aging. Although well‐characterized biochemically and structurally, its substrate selectivity remains unclear: in vitro, Sirt1 appears promiscuous, while in vivo it activates particular processes in response to different stimuli ...
Petra Neumann‐Staubitz +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 39, 13 July 2026.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.ABSTRACT Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by pattern‐recognition receptors such as Toll‐like receptors (TLRs) and RIG‐I–like receptors, play critical ...
Mohammad Enamul Hoque Kayesh +2 more
wiley +1 more source
SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis [PDF]
, 2018 Heart failure is an aging-associated disease that is the leading cause of death worldwide. Sirtuin family members have been largely studied in the context of aging and aging-associated diseases. Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of
Kondapalli, Mrudula S +13 more
core +1 more source
Charakterisierung kernständiger Funktionen der NAD+-abhängigen Deacetylase SIRT2 [PDF]
, 2010 The human Sirtuin SIRT2 is a deacetylase predominantly found in the cytoplasm during the cell cycle, which co-localizes with the chromatin at the G2/M transition. During this transition SIRT2 was described) to deacetylate lysine-16 of histone 4.
Waibel, Susanne
core +2 more sources
TIGAR Maintains Mitotic Spindle Organization and βII‐Tubulin Stability in Glioma Stem Cells
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.This study reveals a novel structural role for TIGAR in glioblastoma stem cells (GSCs). By physically interacting with βII‐tubulin, TIGAR shields it from Parkin‐mediated proteasomal degradation. This axis maintains mitotic spindle integrity and drives GSC proliferation, offering a promising therapeutic target.
Ailin Chen +8 more
wiley +1 more source
Cancer Biology & Medicine, 2019 Objective As a member of the peptidyl arginine deiminase (PAD) family, PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer tissues. However, the role of PADI3 in colon cancer is unclear.
Xiaotian Chang +7 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du +7 more
wiley +1 more source