Results 91 to 100 of about 10,461 (217)

Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. [PDF]

PLoS ONE, 2015
BACKGROUND:Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology.
Ivana Grbesa, María J Pajares, Elena Martínez-Terroba, Jackeline Agorreta, Ana-Matea Mikecin, Marta Larráyoz, Miguel A Idoate, Koraljka Gall-Troselj, Ruben Pio, Luis M Montuenga   +9 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

MicroRNA-339/Sirt2/NF B/FOXO1 Axis [PDF]

, 2020
Recently, we have found that a number of microRNAs (miRNAs) and proteins are involved in the response to acupuncture therapy in hypertensive rats. Our bioinformatics study suggests an association between these miRNAs and proteins, which include miR-339 ...
Shu-Feng Zhou, Jia-Lu Wang, Chun-Mei Ma, Xin-Sheng Lai, Hui Li, Jia-You Wang   +5 more
core  

HF SIRT2 KO mice exhibit increased adiposity and energy expenditure. [PDF]

, 2018
(A) Body weight of the chow WT and SIRT2 KO mice. Lean (B) and fat mass (C) in WT and SIRT2 KO mice on a chow diet at 12 weeks of age. Energy Expenditure (EE) over time (D) or ANCOVA-adjusted 12h average of EE (E) in chow-fed WT or SIRT2 KO mice. RQ over
David H. Wasserman (293778), Curtis C. Hughey (3686770), Louise Lantier (337182), Deanna P. Bracy (6069101), Muhammad A. Ansari (6069104), Freyja D. James (741231), Ashley S. Williams (6069098), David Gius (371493)   +7 more
core   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Lysine benzoylation is a histone mark regulated by SIRT2 [PDF]

Nature Communications, 2018
AbstractMetabolic regulation of histone marks is associated with diverse biological processes through dynamically modulating chromatin structure and functions. Here we report the identification and characterization of a histone mark, lysine benzoylation (Kbz). Our study identifies 22 Kbzsites on histones from HepG2 and RAW cells.
He Huang, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao, Yingming Zhao   +7 more
openaire   +3 more sources

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis [PDF]

, 2010
Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism.
Taylor, David M., Allison Amore, Maxwell, Michele M, Hilary Moffitt, Kazantsev, Aleksey G., Smith, Donna L, Thompson, Leslie M., Steven A. Reeves, Emmanuel Lambert, Ozgun Gokce, Maxwell, Michele M., Gokce, Ozgun, Ruth Luthi-Carter, Christian Neri, Zhongmin Xiang, Leslie M. Thompson, J. Lawrence Marsh, Lambert, Emmanuel, Luthi-Carter, Ruth, Marsh, J. Lawrence, Donna L. Smith, Reeves, Steven A., Taylor, David M, David M. Taylor, Parker, Alex, Alex Parker, Reeves, Steven A, Marsh, J Lawrence, Aleksey G. Kazantsev, Heike Runne, Judit Pallos, Thompson, Leslie M, Moffitt, Hilary, Michele M. Maxwell, Pallos, Judit, Neri, Christian, Smith, Donna L., Bates, Gillian P, Alexandre Kuhn, Bates, Gillian P., Runne, Heike, Amore, Allison, Kuhn, Alexandre, Kazantsev, Aleksey G, Gillian P. Bates, Xiang, Zhongmin   +45 more
core   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source