Results 91 to 100 of about 11,198 (208)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Elucidating the role of SIRT2 in hepatocellular carcinoma through multi-omics and deep learning

Discover Oncology
Background Hepatocellular carcinoma (HCC) is a prevalent global malignancy characterized by a high incidence and poor prognosis. Current diagnostic and therapeutic modalities are insufficient to meet the demands for effective HCC diagnosis and management.
Changan Chen, Tingmei Yang, Caiyuan Yu, Lijiao Cui, Bingjun Cai, Zhenkai Li, Shicai Ye, Yijie Weng   +7 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Structural features of SIRT2.

, 2015
(A) Primary sequences of SIRT2 isoform 1 (SIRT2-iso1) and isoform 2 (SIRT2-iso2) aligned with that of Hst2 from S. cerevisiae (obtained using the BLAST webserver (http://blast.ncbi.nlm.nih.gov/Blast.cgi)).
Patricia Verheugd (800551), Giulia Rossetti (471944), Franziska Flick (800550), Bernhard Lüscher (4729437), Jinyu Li (424996), Paolo Carloni (128984)   +5 more
core   +1 more source

PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer

Cancer Biology & Medicine, 2019
Objective As a member of the peptidyl arginine deiminase (PAD) family, PADI3 is weakly expressed in colon cancer tissues and highly expressed in adjacent colon cancer tissues. However, the role of PADI3 in colon cancer is unclear.
Xiaotian Chang, Zhengbin Chai, Jiaorui Zou, Hongxing Wang, Yao Wang, Yabing Zheng, Hui Wu, Chunyan Liu   +7 more
doaj   +1 more source

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator [PDF]

, 2008
We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna, Murray, Karen E., Stark, Michael J.R., Lain, Sonia, Stark, Michael J. R., Baker, Lee, Appleyard, Virgina, Higgins, Maureen, Pass, Georgia, Mathers, Joanne, Lane, David P., Staples, Oliver D., Woods, Julie, McCarthy, Anna, Holland, Stephen J., Hollick, Jonathan J., Aoubala, Mustapha, Thompson, Alastair, Westwood, Nicholas J., Appleyard, Virginia   +19 more
core   +1 more source

Neuroprotective Effects of Sirt2 Inhibition In Aging

, 2018
Öz bulunamadı.
Aktan, Arzu Keskin, Akbulut, K. Gonca, Akbulut, Hakan   +2 more
openaire   +4 more sources

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis [PDF]

, 2010
Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism.
Taylor, David M., Allison Amore, Maxwell, Michele M, Hilary Moffitt, Kazantsev, Aleksey G., Smith, Donna L, Thompson, Leslie M., Steven A. Reeves, Emmanuel Lambert, Ozgun Gokce, Maxwell, Michele M., Gokce, Ozgun, Ruth Luthi-Carter, Christian Neri, Zhongmin Xiang, Leslie M. Thompson, J. Lawrence Marsh, Lambert, Emmanuel, Luthi-Carter, Ruth, Marsh, J. Lawrence, Donna L. Smith, Reeves, Steven A., Taylor, David M, David M. Taylor, Parker, Alex, Alex Parker, Reeves, Steven A, Marsh, J Lawrence, Aleksey G. Kazantsev, Heike Runne, Judit Pallos, Thompson, Leslie M, Moffitt, Hilary, Michele M. Maxwell, Pallos, Judit, Neri, Christian, Smith, Donna L., Bates, Gillian P, Alexandre Kuhn, Bates, Gillian P., Runne, Heike, Amore, Allison, Kuhn, Alexandre, Kazantsev, Aleksey G, Gillian P. Bates, Xiang, Zhongmin   +45 more
core   +1 more source

SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism

Neoplasia: An International Journal for Oncology Research, 2018
Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory
Yang Li, Mingming Zhang, Robert G. Dorfman, Yida Pan, Dehua Tang, Lei Xu, Zhenguo Zhao, Qian Zhou, Lixing Zhou, Yuming Wang, Yuyao Yin, Shanshan Shen, Bo Kong, Helmut Friess, Shimin Zhao, Lei Wang, Xiaoping Zou   +16 more
doaj   +1 more source

miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson’s Disease

Cellular Physiology and Biochemistry, 2018
Background/Aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in the pathology of Parkinson’s disease (PD). However, the association between potential functional polymorphisms in the SIRT2 gene and PD still needs to be identified.
Yan Wang, YuJie Cai, Haili Huang, Xiongjin Chen, Xiaoyi Chen, Xiaoting Chen, Hui Mai, Xiaohui Li, Jianghao Zhao, Jingqi Yang, Weihao Fan, Pei Tang, Yusen Chen, Keshen Li, Lili  Cui   +14 more
doaj   +1 more source