Results 181 to 190 of about 11,198 (208)

Structure of the histone deacetylase SIRT2.

Nature structural biology, 2001
Sir2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal gene clusters, and has a critical role in the determination of life span in yeast and Caenorhabditis elegans. The 1.7 A crystal structure of the 323 amino acid catalytic core of human SIRT2, a homolog of yeast Sir2, reveals ...
M S, Finnin, J R, Donigian, N P, Pavletich   +2 more
openaire   +2 more sources

Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System

Neurochemical Research, 2006
Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major cell types remodel their shape ...
Cherie M, Southwood, Marcello, Peppi, Sylvia, Dryden, Michael A, Tainsky, Alexander, Gow   +4 more
openaire   +2 more sources

SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy

European Journal of Pharmacology, 2015
Stable microtubules (MTs) is involved the mechanism of diabetic cardiomyopathy (DCM), which is induced by acetylation of α-tubulin. The present study investigated whether SIRT2, a deacetylase, regulates MT stability through α-tubulin deacetylation in DCM and whether the receptor of advanced glycation end products (AGEs) signaling pathway is involved in
Qiong, Yuan, Lin, Zhan, Qian-Yi, Zhou, Li-Li, Zhang, Xu-Meng, Chen, Xia-Min, Hu, Xin-Chu, Yuan   +6 more
openaire   +2 more sources

BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer

Seminars in Cancer Biology
Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate chromosomal segregation and preventing aneuploidy. BubR1 levels have been shown to naturally decline with age and its loss is associated with various age-related ...
Renju, Pun, Niti, Kumari, Rodaina Hazem, Monieb, Sachin, Wagh, Brian J, North   +4 more
openaire   +2 more sources

Assessment of SIRT2 Inhibitors in Mouse Models of Cancer

2019
New therapeutics directed against established and novel molecular targets are urgently needed to intervene against cancer. Recently, it was reported that several members of the sirtuin family (SIRT1-7), the mammalian orthologs of the silent information regulator 2 (Sir2) protein in Saccharomyces cerevisiae, play important roles in carcinogenesis ...
Yashira L, Negrón Abril, Irma, Fernández, Robert S, Weiss   +2 more
openaire   +2 more sources

SIRT2 Mediated Microtubule Acetylation in Osteogenic Differentiation.

The Chinese journal of dental research
To assess the role of microtubule acetylation in the transportation of amorphous calcium phosphate (ACP)-containing vesicles that mediate the osteogenic differentiation process of rat bone mesenchymal stem cells (BMSCs).Rat BMSCs were cultured and transfected with sirtuin 2 (SIRT2) overexpression plasmids for an in vitro model.
Xin Ru, Zhou, Can, Zhang, Chen Rong, Xu, Xin Er, Tan, Qian Qian, Han, Xi, Yang, Tian Yu, Sun, Long Quan, Shao, Jia, Liu   +8 more
openaire   +2 more sources

Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020

European Journal of Medicinal Chemistry, 2021
Mikako Fujita, Geraldene Munsamy, Muhamad Mustafa   +2 more
exaly  

The role of SIRT2 in cancer: A novel therapeutic target

International Journal of Cancer, 2020
Hu Cong, Peng Huang, Guangyuan Chen
exaly  

The role of SIRT2 in vascular‐related and heart‐related diseases: A review

Journal of Cellular and Molecular Medicine, 2021
Yingxian Sun, Boquan Wu
exaly  

SIRT2: Controversy and multiple roles in disease and physiology

Ageing Research Reviews, 2019
Lili Cui, Xiongjin Chen
exaly