Results 181 to 190 of about 10,461 (217)

Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging <i>via</i> H3K4me3-dependent SASP suppression. [PDF]

Acta Pharm Sin B
Chen X, Zhao Q, Chen L, Lin S, Mai B, He X, Zhang X, Chen J, Li S, Li Z, Zhang H, Zhou Y, Li X, Liao H, Ye T, Sun S, Yang Z, Ni S, Lu L.   +18 more
europepmc   +1 more source

Sirtuins and tumor immunity: mechanistic insights, immunotherapy prospects, and therapeutic horizons. [PDF]

Front Immunol
Gu J, Liu S, Xiao W, Qu W.
europepmc   +1 more source

SIRT2 puts the brakes on human β cell proliferation: therapeutic opportunities and next challenges. [PDF]

J Clin Invest
Katz LS, Scott DK, Stewart AF.
europepmc   +1 more source

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling

Tamta AK, Shivanaiah B, Prabhashankar AB, Ningaraju S, Subhadarshini S, Sharma AN, Jayaprakasan HM, E R MK, Bhuyar A, Sunil D, Shrama A, Nagesh D, Munjal A, Raghu S, Madhuri MB, Rajesh D, Ramasubbu V, Sarikhani M, Tandon H, Desingu PA, Diwakar L, Nath U, Nair D, Singh A, Sowdhamini R, Srinivasan N, Mostoslavsky R, Asirvatham-Jeyaraj N, Sundaresan NR.   +28 more
europepmc   +1 more source

The histone deacetylase SIRT2 stabilizes Myc oncoproteins [PDF]

Cell Death and Differentiation, 2012
Myc oncoproteins are commonly upregulated in human cancers of different organ origins, stabilized by Aurora A, degraded through ubiquitin-proteasome pathway-mediated proteolysis, and exert oncogenic effects by modulating gene and protein expression. Histone deacetylases are emerging as targets for cancer therapy. Here we demonstrated that the class III
Tao Liu, Sharad Kumar, Xu Dong Zhang
exaly   +10 more sources

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Src regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a mammalian member of the Sirtuin family of NAD(+)-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization.
You Hee Choi, Hangun Kim, Sung Ho Lee, Yun-Hye Jin, Kwang Youl Lee   +4 more
openaire   +2 more sources

SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy [PDF]

Circulation, 2017
Background: Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure.
Hou-Zao Chen, De-Pei Liu, Minghui Zou
exaly   +2 more sources

Linking SIRT2 to Parkinson’s Disease

ACS Chemical Biology, 2007
A recent study has identified selective inhibitors of the human silent information regulator 2 NAD (+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuclein-mediated toxicity in cellular models of Parkinson's disease.
Adam L, Garske, Brian C, Smith, John M, Denu   +2 more
openaire   +2 more sources