Results 191 to 200 of about 10,461 (217)

Cbl regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell function and development. Cbl proteins are
You Hee, Choi, Hangun, Kim, Younho, Han, Yun-Hye, Jin, Kwang Youl, Lee   +4 more
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SIRT2: Controversy and multiple roles in disease and physiology

Ageing Research Reviews, 2019
Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus. Recently, accumulating evidence has uncovered a growing number of substrates and additional detailed
Lili Cui, Xiongjin Chen
exaly   +3 more sources

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors

Journal of Medicinal Chemistry, 2008
A new inhibitor for human sirtuin type proteins 1 and 2 (SIRT1 and SIRT2) was discovered through virtual database screening in search of new scaffolds. A series of compounds was synthesized based on the hit compound (3-[[3-(4-tert-butylphenyl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-(trifluoromethyl)phenyl]thiourea).
Tero, Huhtiniemi, Tiina, Suuronen, Valtteri M, Rinne, Carsten, Wittekindt, Maija, Lahtela-Kakkonen, Elina, Jarho, Erik A A, Wallén, Antero, Salminen, Antti, Poso, Jukka, Leppänen   +9 more
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SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear.In the present study, we have evaluated the regulatory effects of SIRT2 in lipopolysaccharide (LPS)-stimulated ...
Kyung Pyo Kang, Dal Kim, Tung Nguyen-Thanh   +2 more
exaly   +3 more sources

Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System

Neurochemical Research, 2006
Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major cell types remodel their shape ...
Cherie M, Southwood, Marcello, Peppi, Sylvia, Dryden, Michael A, Tainsky, Alexander, Gow   +4 more
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SIRT2 versus Lck

Science Signaling
Inhibiting the deacetylase SIRT2 increases the activity of the kinase Lck to enhance T cell receptor signaling.
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Assessment of SIRT2 Inhibitors in Mouse Models of Cancer

2019
New therapeutics directed against established and novel molecular targets are urgently needed to intervene against cancer. Recently, it was reported that several members of the sirtuin family (SIRT1-7), the mammalian orthologs of the silent information regulator 2 (Sir2) protein in Saccharomyces cerevisiae, play important roles in carcinogenesis ...
Yashira L, Negrón Abril, Irma, Fernández, Robert S, Weiss   +2 more
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BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer

Seminars in Cancer Biology
Aging is a significant risk factor for cancer which is due, in part, to heightened genomic instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring accurate chromosomal segregation and preventing aneuploidy. BubR1 levels have been shown to naturally decline with age and its loss is associated with various age-related ...
Renju, Pun, Niti, Kumari, Rodaina Hazem, Monieb, Sachin, Wagh, Brian J, North   +4 more
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SIRT2 Mediated Microtubule Acetylation in Osteogenic Differentiation.

The Chinese journal of dental research
To assess the role of microtubule acetylation in the transportation of amorphous calcium phosphate (ACP)-containing vesicles that mediate the osteogenic differentiation process of rat bone mesenchymal stem cells (BMSCs).Rat BMSCs were cultured and transfected with sirtuin 2 (SIRT2) overexpression plasmids for an in vitro model.
Xin Ru, Zhou, Can, Zhang, Chen Rong, Xu, Xin Er, Tan, Qian Qian, Han, Xi, Yang, Tian Yu, Sun, Long Quan, Shao, Jia, Liu   +8 more
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Structure of the histone deacetylase SIRT2.

Nature structural biology, 2001
Sir2 is an NAD-dependent histone deacetylase that mediates transcriptional silencing at mating-type loci, telomeres and ribosomal gene clusters, and has a critical role in the determination of life span in yeast and Caenorhabditis elegans. The 1.7 A crystal structure of the 323 amino acid catalytic core of human SIRT2, a homolog of yeast Sir2, reveals ...
M S, Finnin, J R, Donigian, N P, Pavletich   +2 more
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