Results 171 to 180 of about 11,198 (208)

SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells. [PDF]

Cancer Lett
Patra M, Sadhukhan R, Allen E, Kalantari F, Allam H, Xia F.   +5 more
europepmc   +1 more source

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling. [PDF]

J Clin Invest
Sesay F, Zhang H, Kapoor-Vazirani P, Jung AT, Essien ME, Bastien AJ, Luong NC, Liu X, Head PE, Duong DM, Yang X, Buchwald ZS, Deng X, Seyfried NT, Yu DS.   +14 more
europepmc   +1 more source

Acylglycerol Kinase 2-mediated Inhibition of Sirtuin 2 Restores AMPK/AKT/mTOR Signaling Balance in Podocytes: A Pharmacological Strategy for Diabetic Nephropathy. [PDF]

Iran J Pharm Res
Zahid Piracha Z, Saeed U, Aun Raza SM, Ashraf Z, Muhammad B, Tubaishi Rubab M, Talib A, Nadeem R, Shayan Gilani S, Yar Khan A, Usama Khan M, Uzun Ozsahin D, M Nauli A, M Nauli S.   +13 more
europepmc   +1 more source

miR-4687-5p promotes the progression of diabetic retinopathy by targeting SIRT2 to mediate inflammatory responses. [PDF]

Diabetol Metab Syndr
Zhang Y, Liu S, Wei L, Cui Y.
europepmc   +1 more source

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Src regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a mammalian member of the Sirtuin family of NAD(+)-dependent protein deacetylases. The tyrosine kinase Src is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganization.
Hangun Kim, You Hee Choi, Sung Ho Lee
exaly   +3 more sources

Cbl regulates the activity of SIRT2

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell function and development. Cbl proteins are
You Hee, Choi, Hangun, Kim, Younho, Han, Yun-Hye, Jin, Kwang Youl, Lee   +4 more
openaire   +2 more sources

Linking SIRT2 to Parkinson’s Disease

ACS Chemical Biology, 2007
A recent study has identified selective inhibitors of the human silent information regulator 2 NAD (+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuclein-mediated toxicity in cellular models of Parkinson's disease.
Adam L, Garske, Brian C, Smith, John M, Denu   +2 more
openaire   +2 more sources

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors

Journal of Medicinal Chemistry, 2008
A new inhibitor for human sirtuin type proteins 1 and 2 (SIRT1 and SIRT2) was discovered through virtual database screening in search of new scaffolds. A series of compounds was synthesized based on the hit compound (3-[[3-(4-tert-butylphenyl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-(trifluoromethyl)phenyl]thiourea).
Tero, Huhtiniemi, Tiina, Suuronen, Valtteri M, Rinne, Carsten, Wittekindt, Maija, Lahtela-Kakkonen, Elina, Jarho, Erik A A, Wallén, Antero, Salminen, Antti, Poso, Jukka, Leppänen   +9 more
openaire   +2 more sources

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

Biochemical and Biophysical Research Communications, 2014
SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear.In the present study, we have evaluated the regulatory effects of SIRT2 in lipopolysaccharide (LPS)-stimulated ...
Kyung Pyo Kang, Dal Kim, Tung Nguyen-Thanh   +2 more
exaly   +3 more sources

SIRT2 versus Lck

Science Signaling
Inhibiting the deacetylase SIRT2 increases the activity of the kinase Lck to enhance T cell receptor signaling.
openaire   +2 more sources