Results 21 to 30 of about 8,557 (169)
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases [PDF]
Frontiers in Pharmacology, 2021 Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins.
Ramu Manjula +3 more
openaire +3 more sources
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration
Parkinson's Disease, 2017 Sirtuins are highly conserved lysine deacetylases involved in ageing, energy production, and lifespan extension. The mammalian SIRT2 has been implicated in Parkinson’s disease (PD) where studies suggest SIRT2 promotes neurodegeneration.
Preeti Singh +2 more
doaj +1 more source
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
PLoS ONE, 2014 BackgroundSIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently
Giuseppe Lo Sasso +7 more
doaj +1 more source
Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates
Scientific Reports, 2022 Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase, which regulates multiple biological processes, including genome maintenance, aging, tumor suppression, and metabolism.
Hui Zhang +5 more
doaj +1 more source
Frontiers in Immunology, 2017 Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes.
Eleonora Ciarlo +12 more
doaj +1 more source
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury
Cell Discovery, 2021 Protein acetylation has emerged to play pivotal roles in alcoholic liver disease (ALD). Sirutin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase involved in the regulation of aging, metabolism, and stress.
Yingting Zhang +13 more
doaj +1 more source
SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury
eLife, 2023 Sirtuins (SIRT) exhibit deacetylation or ADP-ribosyltransferase activity and regulate a wide range of cellular processes in the nucleus, mitochondria, and cytoplasm. The role of the only sirtuin that resides in the cytoplasm, SIRT2, in the development of
Xiaoyan Yang +10 more
doaj +1 more source
SIRT2 mediated downregulation of FOXM1 in response to TGFβ through the RAF-MEK-ERK signaling pathway in colon cancer [PDF]
Archives of Biological Sciences, 2021 The transcription factor forkhead box M1 (FOXM1) is frequently upregulated in many solid tumors, including those in the colon. As a master regulator, the sirtuin (SIRT) protein family is comprised of seven nicotinamide adenine dinucleotide (NAD ...
Ozden Ozkan, Park Seong-Hoon
doaj +1 more source
Sirt2 Regulates Radiation-Induced Injury
Radiation Research, 2019 Sirtuin 2 (SIRT2) plays a major role in aging, carcinogenesis and neurodegeneration. While it has been shown that SIRT2 is a mediator of stress-induced cell death, the mechanism remains unclear. In this study, we report the role of SIRT2 in mediating radiation-induced cell death and DNA damage using mouse embryonic fibroblasts (MEFs), progenitor cells ...
Phuongmai, Nguyen +4 more
openaire +3 more sources
npj Parkinson's Disease, 2022 NAD-dependent protein deacetylase Sirtuin 2 (SIRT2), which regulates several cellular pathways by deacetylating multiple substrates, has been extensively studied in the context of Parkinson’s disease (PD). Although several studies based on the MPTP model
Jianguo Yan +9 more
doaj +1 more source