Results 31 to 40 of about 8,557 (169)
Cells, 2021 The sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylase and ADP-ribosyl transferases plays key roles in aging, metabolism, stress response, and aging-related diseases.
Taku Kaitsuka +2 more
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Translational Oncology, 2017 Hepatocellular carcinoma (HCC) is one of the most common neoplasms, and metastasis is the most important feature for HCC-related deaths. Mounting evidence implies the dynamic regulatory role of SIRT2, a histone deacetylase, in cancer cells. Unfortunately,
Shan Huang +11 more
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SIRT2 regulates extracellular vesicle-mediated liver-bone communication
Yearbook of Paediatric Endocrinology, 2023 Abstract The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans.
Longshuai Lin +15 more
openaire +2 more sources
SIRT2 in age-related neurodegenerative disorders
Aging, 2018 Sirtuin 2 (SIRT2) is one of seven members of the NAD+-dependent histone deacetylases (HDAC) family of proteins. Sirtuins play diverse roles in cellular metabolism and the aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria, is highly expressed in the central nervous system (CNS), and has been reported to regulate a variety of ...
Fourcade, Stéphane +2 more
openaire +4 more sources
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. [PDF]
PLoS ONE, 2007 The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a ...
Brian J North, Eric Verdin
doaj +1 more source
Is SIRT2 required for necroptosis? [PDF]
Nature, 2014 Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular processes¹,². Recently Narayan et al., reported that SIRT2 was required for necroptosis based on their findings that SIRT2 inhibition, knock-down or knock-out prevented necroptosis.
Kim, Newton +17 more
openaire +2 more sources
Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway
Frontiers in Pharmacology, 2021 Idiopathic pulmonary fibrosis (IPF) is a fatal disease with unknown cause and limited treatment options. Its mechanism needs to be further explored. Sirtuin2 (Sirt2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, has been proved to be ...
Hui Gong +5 more
doaj +1 more source
Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell. [PDF]
PLoS ONE, 2013 Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization.
Xiaoxing Si +6 more
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Infection Reveals a Modification of SIRT2 Critical for Chromatin Association
Cell Reports, 2018 Summary: Sirtuin 2 is a nicotinamide-adenine-dinucleotide-dependent deacetylase that regulates cell processes such as carcinogenesis, cell cycle, DNA damage, and infection.
Jorge M. Pereira +7 more
doaj +1 more source
SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background and Aims: Intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD).
Chang Li +8 more
doaj +1 more source