Results 111 to 120 of about 84,834 (402)

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity

Pharmaceuticals
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk, John L. Kulp III, Lillian W. Chiang   +2 more
doaj   +1 more source

Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells

Frontiers in Nutrition, 2022
Backgroundalpha-Mangostin, a polyphenolic xanthone, is primarily found in the pericarp of mangosteen throughout Southeast Asia and is considered as the “Queen of Fruit” in Thailand.
Waralee Ruankham, Wilasinee Suwanjang, Kamonrat Phopin, Kamonrat Phopin, Napat Songtawee, Virapong Prachayasittikul, Supaluk Prachayasittikul   +6 more
doaj   +1 more source

RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]

, 2019
Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue, Kim, Il-man, Shen, Yan, Su, Xuan, Tang, Yaoliang, Weintraub, Neal L.   +5 more
core   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

Experimental and Molecular Medicine, 2019
Accumulating evidence has indicated that sirtuins are key components of diverse physiological processes, including metabolism and aging. Sirtuins confer protection from a wide array of metabolic and age-related diseases, such as cancer, cardiovascular ...
In Hye Lee
semanticscholar   +1 more source

Host sirtuin 2 as an immunotherapeutic target against tuberculosis

eLife, 2020
Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence.
Ashima Bhaskar, Santosh Kumar, M. Z. Khan, Ashutosh Kumar Singh, V. Dwivedi, V. Nandicoori   +5 more
semanticscholar   +1 more source

Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations [PDF]

, 2009
Background: Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome.
Banerjee, I., Ben-Omran, T., Chadefaux, B., Chakrapani, A., Ellard, S., Flanagan, S. E, Fulton, P., Hussain, K., Kapoor, R. R, Shield, J. P   +9 more
core   +2 more sources

Sirtuin Catalysis and Regulation [PDF]

Journal of Biological Chemistry, 2012
Sirtuins are a family of NAD(+)-dependent protein deacetylases/deacylases that dynamically regulate transcription, metabolism, and cellular stress response. Their general positive link with improved health span in mammals, potential regulation of pathways mediated by caloric restriction, and growing links to human disease have spurred interest in ...
Jessica L. Feldman, Kristin E. Dittenhafer-Reed, John M. Denu   +2 more
openaire   +3 more sources

The Mechanism and Potential Therapeutic Strategies of Vascular Aging

AGING MEDICINE, EarlyView.
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu, Xuan Wang, Fang‐Fang Wu, Xiao‐Tian Yan, Yong‐Ping Bai   +4 more
wiley   +1 more source