Results 131 to 140 of about 69,505 (315)
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. [PDF]
, 2016 Alterations of specific genes can modulate aging. Myc, a transcription factor that regulates the expression of many genes involved in critical cellular functions was shown to have a role in controlling longevity.
Boyd, Kelli +3 more
core +2 more sources
Flavour and Fragrance Journal, EarlyView.This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou +6 more
wiley +1 more source
Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase [PDF]
, 2017 In response to limited nutrients, fungal cells exit the primary growth phase, enter the stationary phase, and cease proliferation. Although fundamental to microbial physiology in many environments, the regulation of this transition is poorly understood ...
Itoh Eriko +7 more
core +2 more sources
Kathmandu University Medical Journal, 2013 Sirtuins are evolutionary conserved NAD+ dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins represent a promising new class of III NAD dependent histone deacetylases that regulate a number of physiological processes, originally identified in yeast ...
openaire +4 more sources
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. [PDF]
, 2015 Sirtuins are a highly conserved class of NAD(+)-dependent lysine deacylases. The human isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and neurodegeneration, which makes the modulation of Sirt2 activity a promising ...
Karaman, B. +7 more
core +1 more source
Nutrition, sirtuins and aging [PDF]
Genes & Nutrition, 2006 Beyond our inherited genetic make-up environmental factors are central for health and disease and finally determine our life span. Amongst the environmental factors nutrition plays a prominent role in affecting a variety of degenerative processes that are linked to aging.
openaire +2 more sources
A Selective Cyclic Peptidic Human SIRT5 Inhibitor
Molecules, 2016 In the current study, we discovered that a side chain-to-side chain cyclic pentapeptide harboring a central Nε-carboxyethyl-thiocarbamoyl-lysine residue behaved as a strong and selective (versus human SIRT1/2/3/6) inhibitor against human SIRT5-catalyzed ...
Jiajia Liu, Yajun Huang, Weiping Zheng
doaj +1 more source
Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases [PDF]
, 2014 Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated ...
A Duffy +34 more
core +2 more sources
Data in Brief, 2015 Expression of genes associated with inflammation was analyzed during differentiation of human pluripotent stem cells (PSCs) to hepatic cells. Messenger RNA transcript profiles of differentiated endoderm (day 5), hepatoblast (day 15) and hepatocyte-like ...
Joseph Ignatius Irudayam +10 more
doaj +1 more source
Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]
, 2018 Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth +1 more
core +2 more sources