Results 201 to 210 of about 84,834 (402)
The SIRT1 N‐Terminal Domain as a Common Binding Interface for PPARγ Anchoring
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Insulin resistance, a global health threat linked to type 2 diabetes and obesity, can be addressed by modulating the activity of the Sirtuin 1 (SIRT1), a deacetylase that enhances insulin sensitivity by deacetylating the Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) at lysine 268 and 293. Understanding the binding interfaces between
Caique Camargo Malospirito +7 more
wiley +1 more source
Small Science, EarlyView.Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello +5 more
wiley +1 more source
Sirtuin 6: linking longevity with genome and epigenome stability.
Trends in Cell Biology, 2021 A. Korotkov, A. Seluanov, V. Gorbunova
semanticscholar +1 more source
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes [PDF]
, 2009 Shweta Rane +8 more
openalex +1 more source
VIEW, EarlyView.Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang +10 more
wiley +1 more source
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]
, 2019 Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen +20 more
core +1 more source
Reactive Oxygen Species and Age‐Related Genes p66Shc, Sirtuin, FoxO3 and Klotho in Senescence [PDF]
, 2009 Igor B. Afanasʹev
openalex +1 more source
The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression
Aging Cell, EarlyView.A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki +20 more
wiley +1 more source
Aging Cell, EarlyView.Using male vascular endothelial cell–specific Nampt knockout and naturally aged mice, we identified endothelial NAD+ deficiency as a central driver of age‐related angiogenic failure, impaired subcutaneous adipogenesis, and cardiometabolic dysfunction.
Shotaro Kosugi +18 more
wiley +1 more source
Plasmodium falciparum sirtuin 2 (PF13_0152; Sir2); P. falciparum erythrocyte membrane protein 1 (VAR; PfEMP1) [PDF]
, 2009 openalex +1 more source