Results 181 to 190 of about 70,332 (311)

Exercise and the hepatic sirtuin network: rethinking the research focus on SIRT1, SIRT3, and SIRT6. [PDF]

Front Physiol
Kwon JW.
europepmc   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

The SIRT-1/Nrf-2/HO-1 antioxidant defense axis in adult attention-deficit/hyperactivity disorder. [PDF]

Metab Brain Dis
Gürbüzer N, Ozkaya A, Mercantepe F.
europepmc   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

<i>Sechium edule</i> var. <i>nigrum spinosum</i> (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus. [PDF]

Molecules
Gavia-García G, Hernández-Álvarez D, Arista-Ugalde TL, Aguiñiga-Sánchez I, Santiago-Osorio E, Cadena-Iñiguez J, Rosado-Pérez J, Mendoza-Núñez VM.   +7 more
europepmc   +1 more source

Sirtuin regulation of NLRP3 [PDF]

Nature Immunology, 2020
openaire   +2 more sources

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes. [PDF]

Acta Crystallogr F Struct Biol Commun
Weyand M, Quast L, Steegborn C.
europepmc   +1 more source

Effect of Anthocyanin‐Rich New Zealand Blackcurrant on Tumour Necrosis Factor‐α–Induced Plasminogen Activator Inhibitor‐1 Release in Airway Epithelial Cells: A Preliminary Study

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Pretreatment with New Zealand blackcurrant anthocyanins nonsignificantly reduced TNF‐α–induced PAI‐1 release in bronchial epithelial cells. The small sample size may have influenced the lack of statistical significance. This study provides preliminary evidence of possible effects of NZBC anthocyanins on PAI‐1 secretion but warrants further extensive ...
Madiha Ajaz, Ayesha Zahid, Rati Jani, Lada Vugic, Indu Singh, Natalie Shilton   +5 more
wiley   +1 more source

Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback. [PDF]

J Comp Physiol B
O'Brien KM, Cominassi L, Robine S, Marbacher P, Ressel K.   +4 more
europepmc   +1 more source