Results 261 to 270 of about 84,834 (402)

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Structural basis of SIRT2 pre-catalysis NAD⁺ binding dynamics and mechanism. [PDF]

RSC Chem Biol
Zhang N, Pow KC, Chen L, Hao Q.
europepmc   +1 more source

Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity

, 2011
Stephen J. Clark, Mario Falchi, Bob Olsson, Peter Jacobson, Stéphane Cauchi, Beverley Balkau, Michel Marre, Olivier Lantieri, Johanna C. Andersson‐Assarsson, Margareta Jernås, Timothy J. Aitman, Sylvia Richardson, Lars Sjöström, Hang Yee Wong, Lena Carlsson, Philippe Froguel, Andrew J. Walley   +16 more
openalex   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review. [PDF]

Molecules
Budziak S, Kloza M, Krzyżewska A, Baranowska-Kuczko M.   +3 more
europepmc   +1 more source

SIRT2 puts the brakes on human β cell proliferation: therapeutic opportunities and next challenges. [PDF]

J Clin Invest
Katz LS, Scott DK, Stewart AF.
europepmc   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Emerging beneficial roles of sirtuins in heart failure [PDF]

, 2012
Masaya Tanno, Atsushi Kuno, Yoshiyuki Horio, Tetsuji Miura   +3 more
openalex   +1 more source

Correction: Pezzotta et al. Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation. <i>Cells</i> 2022, <i>11</i>, 3316. [PDF]

Cells
Pezzotta A, Perico L, Morigi M, Corna D, Locatelli M, Zoja C, Benigni A, Remuzzi G, Imberti B.   +8 more
europepmc   +1 more source

Sirtuin-1 Targeting Promotes Foxp3⁺ T-Regulatory Cell Function and Prolongs Allograft Survival

, 2011
Ulf H. Beier, Liqing Wang, Tricia Bhatti, Yujie Liu, Rongxiang Han, Guanghui Ge, Wayne W. Hancock   +6 more
openalex   +1 more source