Results 261 to 270 of about 87,529 (407)

Biomolecular Fingerprints of Sirtuin Activity in Senescent Fibroblasts Identified via Synchrotron-Based FTIR. [PDF]

Int J Mol Sci
Fernández-Duran I, Dučić T, Vaquero A.   +2 more
europepmc   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Pharmacology and Therapeutics, 2018
H. Dai, D. Sinclair, J. L. Ellis, C. Steegborn   +3 more
semanticscholar   +1 more source

Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1

Cellular and Molecular Life Sciences, 2021
S. Soni, P. Basu, M. Singaravel, Ramaswamy Sharma, S. Pandi‑Perumal, D. Cardinali, R. Reiter   +6 more
semanticscholar   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Sirtuin Family in Acute Kidney Injury: Insights into Cellular Mechanisms and Potential Targets for Treatment. [PDF]

Biomolecules
Yang S, Chen W, Li S, Zhao S, Cheng F.
europepmc   +1 more source

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

Sirtuin 1 alleviates alcoholic liver disease by inhibiting HMGB1 acetylation and translocation

, 2023
Juan Fu, Wei Deng, Jun Ge, Shengqi Fu, Panpan Li, Huazhi Wu, Jiao Wang, Yi Gao, Hui Gao, Tao Wu   +9 more
openalex   +1 more source

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

Aging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang, Yumin Chang, Aojie He, Jing Yang, Ang Li, Hongqin Wang, Kah‐Leong Lim, Xing Guo, Chengwu Zhang, Li Lu   +9 more
wiley   +1 more source

SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study. [PDF]

Biology (Basel)
Hashimova U, Kvetnoy I, Gaisina A, Safikhanova K, Mironova E, Galandarli I, Hasanli L.   +6 more
europepmc   +1 more source