Results 251 to 260 of about 55,883 (307)

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Deacetylation of SRF catalyzed by SIRT7 protects against abdominal aortic aneurysm formation. [PDF]

Exp Mol Med
Xiong Y, Chen J, Lu W, Liu Y, Sheng C, Liu S, Xu B, Li Y, Pan B, Wang W.   +9 more
europepmc   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival. [PDF]

Geroscience
Ungvari Z, Menyhárt O, Ocana A, Lehoczki A, Fekete M, Bianchini G, Győrffy B.   +6 more
europepmc   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Expression of angiotensin-converting enzyme 2, transmembrane serine protease 2, and sirtuin 1 proteins in lungs of different age groups. [PDF]

J Bras Pneumol
Lamounier ACA, Froio FCL, Ribeiro Júnior G, Costa NSX, Brito JM, Silva-Filho LVRFD, Mauad T.   +6 more
europepmc   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

Pyrroloquinoline Quinone Attenuates Traumatic Brain Injury‐Induced Secondary Damage by Activating PINK1/Parkin‐Mediated Mitophagy and Suppressing ASS1/CPS1‐Driven Arginine Biosynthesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pyrroloquinoline quinone (PQQ) attenuates traumatic brain injury in mice. Multi‐omics integration and molecular docking reveal that PQQ activates PINK1/Parkin‐mediated mitophagy to restore mitochondrial homeostasis while suppressing ASS1/CPS1‐driven arginine biosynthesis to dampen neuroinflammation, identifying a dual‐axis therapeutic mechanism for TBI.
Yanan He, Lu Yu, Yixun Lu, Zhikang Zhou, Ao Li, Lu Wang, Zhili Huang, Yanhong Liu, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Research progress on multi-mechanism analysis and protection strategies of ovarian aging and fertility decline. [PDF]

J Ovarian Res
Chen J, Duan X, Jing Y, Liu X, Zhang Y, Tang Y, Chen C, Yang J, Li X, Lin F, Zhao L.   +10 more
europepmc   +1 more source