Results 261 to 270 of about 55,883 (307)
Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol. [PDF]
Front PharmacolAmegble K +5 more
europepmc +1 more source
The NF-κB pathway in inflammatory responses in preeclampsia: A systematic review and meta-analysis. [PDF]
Medicine (Baltimore)Zhang H, Nong Y, Huang M, Wei R, Feng L.
europepmc +1 more source
Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis. [PDF]
NeuronDierckx T +18 more
europepmc +1 more source
Bioactive Compounds from Medicinal and Edible Plants for Anti-Aging: A Systematic Review of Molecular Mechanisms, Delivery Systems, and Clinical Evidence. [PDF]
FoodsMa Z +5 more
europepmc +1 more source
Mechanistic Studies of Lactate in Heart Failure: From Metabolic Biomarker to Therapeutic Target. [PDF]
Rev Cardiovasc MedZhang Z, Zeng T, Li X, He Z, Li S.
europepmc +1 more source
Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors [PDF]
International Journal of Molecular Sciences, 2021 Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells.
Rina Meidan +2 more
exaly +3 more sources
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Expert Opinion on Therapeutic Patents, 2009
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
Annual Review of Biochemistry, 2006
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
openaire +2 more sources
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
openaire +2 more sources