Results 241 to 250 of about 55,883 (307)

Ramelteon and Mortality in Patients With Sepsis and Cancer: Insights From a Propensity‐Matched Analysis of the MIMIC‐IV Database

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Purpose This study aimed to evaluate the association between ramelteon use and mortality outcomes in patients with sepsis and cancer. The research question was whether ramelteon use is associated with reduced mortality in this high‐risk patient population. Methods A retrospective analysis of the MIMIC‐IV database was conducted.
Chendong Wang, Mingjie Liu, Jia Song
wiley   +1 more source

Correction: Exercise and the hepatic sirtuin network: rethinking the research focus on SIRT1, SIRT3, and SIRT6. [PDF]

Front Physiol
Kwon JW.
europepmc   +1 more source

Classification, Structure–Activity Relationship, and Anti‐Osteoarthritis Mechanism of Natural Flavonoids

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang, Shuqi Zheng, Chunlei Hua, Wanze Feng, Zengxia Liu, Yanhong Sun, Minhui Li   +6 more
wiley   +1 more source

Visceral Obesity and Its Complications: The Role of Bioelectrical Impedance Analysis in Longevity Medicine. [PDF]

Metabolites
Mariotti M, Merenda V, Arrigoni F, Tamburlin N.   +3 more
europepmc   +1 more source

Revising NHE‐1: From Cardiac Homeostasis to Heart Failure and Future Drug Development

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT NHE‐1 is a Na+/H+ exchanger that receives phosphorylation signals, binds calmodulin and responds to neurohormonal input from angiotensin II, endothelin‐1, and adrenergic pathways. In cardiac myocytes, NHE‐1 maintains pH homeostasis and couples to Na+/Ca2+ exchange and mitochondrial ion handling. During heart disease sustained activation drives
Vasileios Bouratzis, Nikoleta Douskou, Nikolaos P. Tzavellas, Yannis V. Simos, Petros Bozidis, Konstantinos I. Tsamis, Georgios S. Markopoulos, Dimitrios Peschos, Lampros Lakkas   +8 more
wiley   +1 more source

The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1. [PDF]

Biochemistry
Richter SM, Bui HL, Chen A, Tannous C, Butler BR, Bennett SD, Nguyen SQ, Prado J, Nhan R, Mohamed A, DuBois IA, Tadros E, Thai NT, Lima Guan S, Peralta CM, Kwong A, Hawk LML, Grazioli G, Wang N.   +18 more
europepmc   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction. [PDF]

Phytother Res
Wu B, Xiao J, Luo Z, Chen Z, Jian G, Lu Y, Ye X, Shu Y, Tan Z, Dong L, Liao X.   +10 more
europepmc   +1 more source

Dual miRNA‐Mediated Axes Act in Concert in the Antioxidant Action of Eicosapentaenoic Acid: let‐7c‐3p/TFAM Drives Mitochondrial Biogenesis While miR‐34c‐5p/SIRT1 Potentiates Enzymatic Defenses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Previous transcriptomic analysis revealed that eicosapentaenoic acid (EPA) alters miRNA expression in HepG2 cells. Two key miRNA‐mRNA axes mediating EPA's antioxidant effects were identified. EPA was found to downregulate let‐7c‐3p, which directly targets mitochondrial transcription factor A (TFAM).
Haiqi Wang, Yanqi Lin, Yuanyuan Li, Xiaowen Wu, Jingyu Lin, Shiying Huang, Guiling Li   +6 more
wiley   +1 more source

[Retracted] Ultrasound‑targeted microbubble destruction‑mediated overexpression of Sirtuin 3 inhibits the progression of ovarian cancer. [PDF]

Oncol Rep
Cheng L, Zhang D, Yan W.
europepmc   +1 more source