Results 231 to 240 of about 70,332 (311)

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL‐Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

Aging Cell, Volume 25, Issue 5, May 2026.
Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li, Jian Wu, Rui Liu, Qiang Li, Fei Xue   +4 more
wiley   +1 more source

Association Between Salivary Sirtuin-1 Levels and Periodontitis. [PDF]

J Clin Med
Lorente L, Marrero EH, Abreu González P, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, Jiménez A, Hernández Padilla CM.   +9 more
europepmc   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Biomolecular Fingerprints of Sirtuin Activity in Senescent Fibroblasts Identified via Synchrotron-Based FTIR. [PDF]

Int J Mol Sci
Fernández-Duran I, Dučić T, Vaquero A.   +2 more
europepmc   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Vitamin K2 Extends Lifespan by Alleviating Mitochondrial Stress via the JNK‐1/SIR‐2.1/DAF‐16 Signaling Axis in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 5, May 2026.
Vitamin K2 activates the JNK‐1/SIR‐2.1/DAF‐16 signaling axis in C. elegans, alleviating mitochondrial stress, reducing ROS accumulation, preserving mitochondrial function, and extending lifespan. These findings reveal a novel anti‐aging mechanism of Vitamin K2 through mitochondrial protection and stress resistance enhancement.
Song‐Yu Guo, Yu‐Qi Li, Hua Piao, Wen‐Fei Zheng, Si‐Qi Li, Ze‐Yang Liu, Jun‐Ting Lv, Yue Kong, Qi‐Fa Li, Ying‐Zi Wang, Shu‐Zhuang Li, Chun‐Li Zhao, Shao Li   +12 more
wiley   +1 more source

Relationship between vitamin D and surrogate parameters (leukocyte telomerase length, telomerase activity), and genes (<i>ACTN3, FOXO3A, VDR, SIRT1, MSTN</i>) for ageing in Asian Indian with prediabetes. [PDF]

Front Endocrinol (Lausanne)
Bhatt SP, Khurana A, Pandey S, Misra A.
europepmc   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, Volume 183, Issue 10, Page 2592-2612, May 2026.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Induced Pluripotent Stem Cells derived CD71^＋CD235a^＋ Erythroblasts Were Increased by Sirtuin 1 Activator. [PDF]

Int J Stem Cells
Kim C, Park KH, Jeon SB, Han AR, Lee JY, Yoon YS.   +5 more
europepmc   +1 more source

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source