Results 231 to 240 of about 55,883 (307)

Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, Volume 7, Issue 3, Page 99-108, September 2026.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Evaluation of Molecular Responses and Longevity Markers in <i>Acheta domesticus</i> Following Combined Resveratrol and Nanodiamond Exposure. [PDF]

Int J Mol Sci
Ziętara-Krzyk P, Flasz B, Augustyniak M.   +2 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Dapagliflozin Protects Cardiomyocytes against Doxorubicin-Induced Toxicity by Modulating Sirtuin 1/Sirtuin 3 and Ferroptosis Pathway. [PDF]

ACS Pharmacol Transl Sci
Khine HEE, Mangmool S, Parichatikanond W.   +2 more
europepmc   +1 more source

Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience—A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
Music and physical exercise share convergent neurobiological mechanisms, including neuroplasticity, metabolic regulation, and neuroinflammatory modulation. Integrating music with exercise produces synergistic effects that enhance brain function beyond single interventions.
Sanxia Yang, Qingluan Liu, Minghui Wang, Yidan Zhang   +3 more
wiley   +1 more source

Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]. [PDF]

Drug Des Devel Ther
europepmc   +1 more source

Research progress on metabolic abnormalities in myocardial hypertrophy. [PDF]

Front Cardiovasc Med
Liu X, Liu Y, Huang M, Ouyang F, Li Y.
europepmc   +1 more source

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

Intestinal Sirtuin 1 Controls Liver Regeneration via Regulating the Intestinal Farnesoid X Receptor/Fibroblast Growth Factor 15 Axis in Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Seaman S, Ruiz P, Nirello VD, Martin-Castilla L, Elizalde-Garcia P, Vega-Zuza A, Vegas-Petrina L, Lumbreras-Perales C, Philo M, Moreno-Gonzalez M, Varga-Weisz P, Beraza N.   +11 more
europepmc   +1 more source