Results 271 to 280 of about 74,229 (355)

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

Investigating the Origins of Biochemical Dysregulation in Trisomy 21 Pregnancy.

J Clin Endocrinol Metab
Buczyńska A, Sidorkiewicz I, Krętowski AJ, Zbucka-Krętowska M.   +3 more
europepmc   +1 more source

Correction to: Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development. [PDF]

Cell Biol Toxicol
Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B.   +7 more
europepmc   +1 more source

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

Aging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang, Yumin Chang, Aojie He, Jing Yang, Ang Li, Hongqin Wang, Kah‐Leong Lim, Xing Guo, Chengwu Zhang, Li Lu   +9 more
wiley   +1 more source

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function

Aging Cell, Volume 25, Issue 2, February 2026.
In D‐galactose‐induced aging model, periodic therapeutic phlebotomy exerts significant and comprehensive anti‐aging effects by inducing bone marrow microenvironment restoration, which rebalances hematopoiesis to restore peripheral blood function and ameliorate systemic aging phenotypes.
Ji‐Ru Cai, Jian Zhang, Yue‐Xin Ning, Jing Zhang, Tian‐Ce Xu, Mei‐Chen Liu, Ke‐Xin Wang, Hui‐Sheng Chen   +7 more
wiley   +1 more source

Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study [PDF]

Hadi Sayedyousef, Onur Yılmaz, Cengizhan Öztürk, Becen Demir, Hilal Uslu Toygar, Nur Balcı   +5 more
openalex   +1 more source

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, Volume 59, Issue 2, February 2026.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

Explore sirtuin family: SIRT5 as a ticket for the entrance of the TBK1-RelA axis to skeletal muscle rejuvenation. [PDF]

Life Med
europepmc   +1 more source

Sirtuin 4 Knockout Aggravates Sepsis-Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes. [PDF]

Mediators Inflamm
Li N, Ma D, Luo S, He A, Chang S.
europepmc   +1 more source

BindingDB Entry 13226: SMALL MOLECULE SIRTUIN INHIBITORS AND USES THEREOF

BindingDB
openalex   +1 more source