Results 281 to 290 of about 84,834 (402)

MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation

Circulation, 2018
Xiaokan Zhang, R. Ji, Xianghai Liao, E. Castillero, P. Kennel, D. Brunjes, M. Franz, S. Möbius‐Winkler, Konstantinos Drosatos, Isaac George, Emily I. Chen, Paolo C. Colombo, P. C. Schulze, P. C. Schulze   +13 more
semanticscholar   +1 more source

Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging

, 2011
Leonard Guarente
openalex   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, Volume 9, Issue 10, October 2025.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Correction: Berberine ameliorates subarachnoid hemorrhage injury via induction of Sirtuin 1 and inhibiting HMGB1/Nf-κB pathway. [PDF]

Front Pharmacol
Zhang XH, Peng L, Zhang J, Dong YP, Wang CJ, Liu C, Xia DY, Zhang XS.   +7 more
europepmc   +1 more source

Surgical Residents Make Significant Contributions to Ongoing Cancer Research [PDF]

, 2009

core   +1 more source

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, Volume 35, Issue 42, October 15, 2025.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Dietary compounds activates sirtuins - a computational modeling approach towards the management of ageing. [PDF]

BMC Biotechnol
Besli N, Kaya MT, Ercin N, Celik U.
europepmc   +1 more source

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Cell Metabolism, 2019
H. Amano, A. Chaudhury, Cristian Rodríguez-Aguayo, Lan-Ying Lu, Viktor Akhanov, A. Catic, Y. Popov, E. Verdin, Hannah L. Johnson, F. Stossi, D. Sinclair, Eiko Nakamaru-Ogiso, G. Lopez-Berestein, Jeffrey T. Chang, J. Neilson, A. Meeker, M. Finegold, J. Baur, Ergun Sahin   +18 more
semanticscholar   +1 more source

Sirtuin regulation of NLRP3 [PDF]

Nature Immunology, 2020
openaire   +3 more sources

Restoration of SIRT3 Expression in Aged Mice Alleviates UUO‐Induced Renal Fibrosis by Reducing GSK‐3β Hyperacetylation

Advanced Science, Volume 12, Issue 39, October 20, 2025.
SIRT3 expression is significantly downregulated in the aged kidney, rendering the kidney more vulnerable to fibrotic changes in obstructive nephropathy. By promoting GSK‐3β deacetylation, SIRT3 indirectly inhibits Wnt/β‐catenin signaling, thereby suppressing renal fibrosis.
Jing Wang, Xiang Ren, Huan Lu, Zihao Guo, Xing Li, Yiqun Tian, Yisheng Yin, Zhenliang Qin, Kun Yun, Minglong Wu, Gang Chen, Xiaoyong Zeng   +11 more
wiley   +1 more source