Results 111 to 120 of about 63,033 (309)

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease [PDF]

, 2008
Carl Julien, Cyntia Tremblay, Vincent Émond, Meryem Lebbadi, Norman Salem, David A. Bennett, Frédéric Calon   +6 more
openalex   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M, Guo, L, Moss, SE, Shi, H, Stampoulis, D, Williams, JA   +5 more
core   +1 more source

Persimmon carotenoid extract rich in β‐cryptoxanthin improves glucose homeostasis and reduces liver damage in high‐fat‐diet‐induced type 2 diabetic and metabolic dysfunction‐associated steatotic liver disease mice

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β‐cryptoxanthin
Bryan Moreno‐Chamba, Nuria Martí, Antonio Cárdenas, María Soledad Fernández‐Pachón, Blanca Escudero‐López, Franz Martín, Julio Salazar‐Bermeo, Manuel Valero, Domingo Saura, María Concepción Martínez‐Madrid, Genoveva Berná   +10 more
wiley   +1 more source

The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice

Neural Regeneration Research
[INLINE:1] Studies have shown that C1q/tumor necrosis factor-related protein-6 (CTRP6) can alleviate renal ischemia/reperfusion injury in mice. However, its role in the brain remains poorly understood.
Bo Zhao, Mei Li, Bingyu Li, Yanan Li, Qianni Shen, Jiabao Hou, Yang Wu, Lijuan Gu, Wenwei Gao   +8 more
doaj   +1 more source

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes [PDF]

, 2009
Shweta Rane, Minzhen He, Danish Sayed, Himanshu Vashistha, Ashwani Malhotra, Junichi Sadoshima, Dorothy E. Vatner, Stephen F. Vatner, Maha Abdellatif   +8 more
openalex   +1 more source

USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osimertinib (OSI) resistance in non‐small cell lung cancer (NSCLC) remains a significant challenge. This report explored the precise role of USP28 on OSI resistance in NSCLC and identified a functional downstream effector. OSI‐resistant H1975 cells (H1975/OSI) were established by long‐term OSI exposure.
Hu‐Sen Fan, Xiu‐Mei Li, Jia‐Qi Gu, Hai‐Feng Wang, Zhen‐Jiang Zhang   +4 more
wiley   +1 more source

Emerging Evidence concerning the Role of Sirtuins in Sepsis

Critical Care Research and Practice, 2018
Sepsis, a dysregulated host response to infection, is a major public health concern. Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood.
Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng   +4 more
doaj   +1 more source

Plasmodium falciparum sirtuin 2 (PF13_0152; Sir2); P. falciparum erythrocyte membrane protein 1 (VAR; PfEMP1) [PDF]

, 2009

openalex   +1 more source

NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial

The Laryngoscope, EarlyView.
This 2‐year, single‐center, double‐blind study with a small sample size compared NAD+ and control groups in a randomized controlled trial for sudden sensorineural hearing loss (SSNHL). Results showed that NAD+ led to better hearing improvement from 7 days to 3 months and a shorter average recovery time compared to the control group.
Minqian Gao, Yingting Guan, Xuejing Yue, Hao Bao, Qianwen Li, Yiqing Zheng, Yongkang Ou, Haidi Yang   +7 more
wiley   +1 more source