Results 61 to 70 of about 65,710 (330)
Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]
, 2016 Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F. +4 more
core +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The role of Sirtuin1-PPARγ axis in placental development and function. [PDF]
, 2018 Placental development is important for proper in utero growth and development of the fetus, as well as maternal well-being during pregnancy. Abnormal differentiation of placental epithelial cells, called trophoblast, is at the root of multiple pregnancy ...
Arul Nambi Rajan, Kanaga +3 more
core +1 more source
Sirtuin 1 ve Sirtuin 2’nin Tip 2 Diyabet ile İlişkisi
Turkish Journal of Diabetes and Obesity, 2021 Diabetes mellitus is the most common endocrine disease in the world and in all age groups. Type 2 diabetes is a disease that constitutes approximately 80-90% of diabetes cases and typically occurs in advanced ages. The pathogenesis of type 2 diabetes is quite complex and is still a matter of debate in many aspects.
ULU, İlke +2 more
openaire +3 more sources
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2021 Inflammation and neonatal hypoxia-ischemia (HI) are important etiological factors of perinatal brain injury. However, underlying mechanisms remain unclear.
Gagandeep Singh-Mallah +11 more
doaj +1 more source
Antagonizing CD105 enhances radiation sensitivity in prostate cancer. [PDF]
, 2018 Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery.
Andres, Allen +9 more
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Sirtuins, bioageing, and cancer [PDF]
, 2011 The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
McCaul, J. +3 more
core +4 more sources