Results 61 to 70 of about 23,914,328 (286)

Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors

Circulation: Heart Failure, 2020
The cardioprotective effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors may be related to their ability to induce a fasting-like paradigm, which triggers the activation of nutrient deprivation pathways to promote cellular homeostasis.
M. Packer
semanticscholar   +1 more source

Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence

Cell Proliferation, 2021
Premature senescence is related to progerin and involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis.
Xiaoying Luo, Yangqiu Bai, Shuli He, Suofeng Sun, Xiaoke Jiang, Zhiyu Yang, Di Lu, P. Wei, Yuan Liang, C. Peng, Yaru Wang, Ruli Sheng, Shuangyin Han, Xiuling Li, Bingyong Zhang   +14 more
semanticscholar   +1 more source

Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients [PDF]

, 2015
Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes.
Agorreta, Jackeline, Gall-Troselj, Koraljka, Grbeša, Ivana, Idoate, Miguel A., Larráyoz, Marta, Martínez-Terroba, Elena, Mikecin, Ana-Matea, Montuenga, Luis M., Pajares, María J., Pio, Ruben   +9 more
core   +6 more sources

Serum sirtuin 1 is independently associated with intact PTH among patients with chronic kidney disease

Clinical Interventions in Aging, 2021
Angelika Bielach-Bazyluk,1 Edyta Zbroch,2 Katarzyna Czajkowska,1 Ewa Koc-Zorawska,1 Katarzyna Kakareko,1 Alicja Rydzewska-Rosolowska,1 Tomasz Hryszko1 1 2nd Department of Nephrology and Hypertension with Dialysis Centre, Medical University, Bialystok ...
Bielach-Bazyluk A, Zbroch E, Czajkowska K, Koc-Zorawska E, Kakareko K, Rydzewska-Rosolowska A, Hryszko T   +6 more
doaj  

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Inverse association of circulating SIRT1 and adiposity. A study on underweight, normal weight, and obese patients [PDF]

, 2018
Context: Sirtuins (SIRTs) are NAD+-dependent deacetylases, cellular sensors to detect energy availability, and modulate metabolic processes. SIRT1, the most studied family member, influences a number of tissues including adipose tissue.
Barbaro G, BASCIANI, Sabrina, CONTINI, SAVINA, DI GIORGIO, MARIA ROSARIA, Donini LM, Genco A, GNESSI, Lucio, Lenzi A, LUBRANO, Carla, MARIANI, Stefania, Persichetti A, Poggiogalle E, Rosano A, SAN MARTINI, Pietro, SARNICOLA, Antonio   +14 more
core   +1 more source

Epigenetic Regulation Associated With Sirtuin 1 in Complications of Diabetes Mellitus

Frontiers in Endocrinology, 2021
Diabetes mellitus (DM) has been one of the largest health concerns of the 21st century due to the serious complications associated with the disease. Therefore, it is essential to investigate the pathogenesis of DM and develop novel strategies to reduce ...
Jie Wang(a), Shudong Wang, Jie Wang(b), Mengjie Xiao, Yuanfang Guo, Yufeng Tang, Jingjing Zhang, J. Gu   +7 more
semanticscholar   +1 more source

Effects of sirtuin 1 deficiency on trophoblasts and its implications in the pathogenesis of pre-eclampsia

Journal of Obstetrics and Gynaecology, 2023
Background Sirtuin 1 (SIRT1) is mainly localised in syncytiotrophoblasts and cytotrophoblasts, and is involved in pregnancy regulation. However, data on the association between SIRT1 and pre-eclampsia (PE) remains limited. This study aimed to investigate
Hongbiao Yu, Ling Chen, Ping Du, Xianping Liu, Ying Xia   +4 more
doaj   +1 more source

Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury

Journal of Cellular and Molecular Medicine, 2021
Sirtuin 1 (SIRT1) plays a very important role in a wide range of biological responses, such as metabolism, inflammation and cell apoptosis. Changes in the levels of SIRT1 have been detected in the brain after traumatic brain injury (TBI).
Guan Wei, Jiawei Wang, Yanbing Wu, Xiaoxin Zheng, Yile Zeng, Yasong Li, Xiangrong Chen   +6 more
semanticscholar   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources