Results 81 to 90 of about 63,033 (309)

Sirtuin-1 level and gene polymorphisms in multiple sclerosis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Sirtuin-1 (SIRT1) may affect multiple sclerosis (MS) disease. This study aimed to investigate the level of serum SIRT1, mRNA expression and genetic polymorphisms in Egyptian MS sufferers.
Rania S. Nageeb, Amal Fawzy, Marwa Abdel-Monem Ateya, Aliaa Talaat   +3 more
doaj   +1 more source

Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs

Journal of Research in Medical Sciences, 2019
Background: Type 2 diabetes (T2DM) is characterized by hyperglycemia and insulin deficiency. Sirtuin 1 (SIRT1), serving as a deacetylase, is critical in the regulation of glucose and lipid metabolism.
Ozlem Gok, Zeynep Karaali, Arzu Ergen, Sema Sirma Ekmekci, Neslihan Abaci   +4 more
doaj   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations [PDF]

, 2009
Background: Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome.
Banerjee, I., Ben-Omran, T., Chadefaux, B., Chakrapani, A., Ellard, S., Flanagan, S. E, Fulton, P., Hussain, K., Kapoor, R. R, Shield, J. P   +9 more
core   +2 more sources

Sirtuin 1 and Hormonal Regulations in Aging

Applied Sciences
Aging affects the structure and functions of all organs and systems in the organism. In the elderly, significant changes in hormonal levels are observed.
Milena Keremidarska-Markova, Iliyana Sazdova, Mitko Mladenov, Bissera Pilicheva, Plamen Zagorchev, Hristo Gagov   +5 more
doaj   +1 more source

Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Nicotine has been associated with cognitive functions such as memory and attention, with serum neurofilament light chain (sNfL) as a biomarker for neurological diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS).
Qianqian Ji, Erhan Tang, Yueting Liao, Jialei Yang, Yunzhang Wang, Yiqiang Zhan   +5 more
wiley   +1 more source

Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity [PDF]

, 2016
Background and aim: Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk.
A. Lenzi, C. Caldaroni, C. Lubrano, D. Costantini, E. Poggiogalle, G. Barbaro, L. Gnessi, L.M. Donini, S. Basciani, S. Mariani   +9 more
core   +1 more source

Recent Advances of In Situ Anticancer Nanomedicine from Enzyme‐Instructed Self‐Assembly

ChemNanoMat, EarlyView.
This review summarizes advances in enzymatic self‐assemblies for generating in situ anticancer nanomedicine over the past five years. It highlights the unique features of enzyme substrates for in situ anticancer nanomedicine by discussing the representative examples.
Linrui Zou, Meihui Yi, Bing Xu
wiley   +1 more source

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues [PDF]

, 2017
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl) benzoyl chloride.
Heugebaert, Thomas, Kerchev, Pavel, Stevens, Christian, Van Breusegem, Frank, van der Meer, Tom, Verlee, Arno   +5 more
core   +3 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source