Results 161 to 170 of about 17,907 (258)

Dietary Bioactives and Physical Activity in the Regulation of Hippocampal Neurogenesis and Cognitive Decline

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Exercise and dietary polyphenols enhance hippocampal plasticity and cognitive function via complementary molecular mechanisms. Central pathways include BDNF signaling, inflammation control, and mitochondrial regulation. Although synergy is mainly supported by preclinical data, lifestyle‐based strategies show promise for brain health maintenance ...
Zhenyi Zhao, Sima‐sadat Sabihi
wiley   +1 more source

Sirtuins Contribute to the Migraine-Stroke Connection. [PDF]

Int J Mol Sci
Krekora J, Fila M, Mitus-Kenig M, Pawlowska E, Ciupinska J, Blasiak J.   +5 more
europepmc   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

NAD⁺ Homeostasis and Autophagy: Integrated Control Through Nutrient Signaling in Yeast and Mammals. [PDF]

Cells
McDaniel M, Lee LH, Lin SJ.
europepmc   +1 more source

An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective sensitizers.
Mohammad Ashraful Islam, Al Amin, Md. Abdul Aziz, Md. Mahabubur Rahaman, Jakir Hossain, Jakir Ahmed Chowdhury, Mohammad Safiqul Islam   +6 more
wiley   +1 more source

From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine. [PDF]

Molecules
Nicoletti GRP, Mangano K, Nicoletti F, Cavalli E.   +3 more
europepmc   +1 more source

SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL

PHYSIOLOGICAL REVIEWS, 2013
Ruben Nogueiras, Kirk M. Habegger, Nilika Chaudhary, Brian Finan, Alexander S. Banks   +4 more
openaire  

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Move beyond free radical theory of aging

iMetaOmics, Volume 3, Issue 1, March 2026.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms. [PDF]

J Neurochem
Perez Lao EJ, Fagerli E, Ferrier F, Young JI, Perez-Pinzon MA.   +4 more
europepmc   +1 more source