Berberine and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Hope or Hype?
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Ruth Nona, Eric Kalo
wiley +1 more source
Nicotinamide Reverses the Warburg Effect in CHO Cell Culture
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1902-1915, July 2026.ABSTRACT The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey +7 more
wiley +1 more source
The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation. [PDF]
Chem Res ToxicolSin YC, Zhao L.
europepmc +1 more source
Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease
Brain and Behavior, Volume 16, Issue 7, July 2026.In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu +3 more
wiley +1 more source
Knockdown of mitochondrial sirtuin sir-2.2 reduces alpha-synuclein clearance and impairs energy homeostasis in a model of ageing. [PDF]
Dis Model MechNaseer A, Toppo P, Akbar M, Nazir A.
europepmc +1 more source
Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits
Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
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The crosstalk between MicroRNAs and sirtuins: a bit unexpected therapeutic target for cardiovascular diseases. [PDF]
Eur J Med ResKamvar R +8 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.Chronic cerebral hypoperfusion induces endothelial hypoxic stress. During the early adaptive phase, the HCG11/QKI5 axis acts upstream of HIF‐1α/VEGF signaling to promote compensatory angiogenesis. With prolonged hypoperfusion, this regulatory pathway declines, leading to impaired vascular adaptation.
Xueqiao Jiao +9 more
wiley +1 more source
Oxidative Stress, Mitochondrial Quality Control, Autophagy, and Sirtuins in Heart Failure. [PDF]
Int J Mol SciKrekora J +4 more
europepmc +1 more source