Results 161 to 170 of about 18,502 (257)

Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback. [PDF]

J Comp Physiol B
O'Brien KM, Cominassi L, Robine S, Marbacher P, Ressel K.   +4 more
europepmc   +1 more source

The Divergent Effects of Nicotinamide Riboside and High‐Intensity Exercise Training on Skeletal Muscle Epigenetic Aging

Aging Cell, Volume 25, Issue 8, August 2026.
This study investigated the effects of nicotinamide riboside supplementation and high‐intensity interval training on skeletal muscle epigenetic aging. Our findings reveal that both interventions may modify epigenetic aging, with the muscle‐specific MEAT and DunedinPACE clocks showing the most responsiveness and links to mitochondrial abundance ...
Aino Heikkinen, Liina Uusitalo‐Kylmälä, Ida Blom, Jørn Wulff Helge, Linn Gillberg, Robert Seaborne, Steen Larsen, Macsue Jacques, Robin Grolaux, Sari Aaltonen, Jaakko Kaprio, Birgitta W. van der Kolk, Sini Heinonen, Nir Eynon, Kirsi H. Pietiläinen, Riikka Kivelä, Eija Pirinen, Miina Ollikainen   +17 more
wiley   +1 more source

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans. [PDF]

Genetics
Chang SM, Franklin LP, Sattar S, Moro CA, DeGennaro MV, LaGanke NG, Hanna-Rose W.   +6 more
europepmc   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Evaluation of Molecular Responses and Longevity Markers in <i>Acheta domesticus</i> Following Combined Resveratrol and Nanodiamond Exposure. [PDF]

Int J Mol Sci
Ziętara-Krzyk P, Flasz B, Augustyniak M.   +2 more
europepmc   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Oxidative Stress, Mitochondrial Homeostasis, and Sirtuins in Atrial Fibrillation. [PDF]

Int J Mol Sci
Krekora J, Pawlowska E, Derwich M, Drożdż J, Blasiak J.   +4 more
europepmc   +1 more source

Factors Determining Sirtuin‐1 Target Engagement

Advanced Biology, Volume 10, Issue 7, July 2026.
ABSTRACT Sirtuin‐1 (Sirt1) is a key NAD+‐dependent deacylase regulating metabolism, stress responses, genome stability, and aging. Although well‐characterized biochemically and structurally, its substrate selectivity remains unclear: in vitro, Sirt1 appears promiscuous, while in vivo it activates particular processes in response to different stimuli ...
Petra Neumann‐Staubitz, Yannick Burgdorf, Sarah Hofmann, Heinz Neumann   +3 more
wiley   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Role of histone deacetylases and sirtuins in the ischaemic stroke: a systematic review and meta-analysis of animal studies. [PDF]

Stroke Vasc Neurol
Majdi A, Yaraghi S, Moharrami A, Ghaffari Tabrizi A, Dojahani M, Alirezapour E, Mansori K, Eskandari M, Mostafavi H.   +8 more
europepmc   +1 more source