Results 161 to 170 of about 22,350 (290)

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

The Sirtuin Network: Linking NAD⁺ Metabolism, Mitochondrial Function, and Metabolic Homoeostasis. [PDF]

Diabetes Metab Res Rev
Szczęsny-Małysiak E, Schiavoni V, Rotondo R, Zeppa SD, Vignini A, Moriconi E, Cecati M, Armani A, Gorini S, Campagna R, Caprio M.   +10 more
europepmc   +1 more source

Oxidative Stress–Driven Alterations in FoxO‐1 and MMP‐9 Activity in Smoking‐Associated Periodontitis

Oral Diseases, EarlyView.
ABSTRACT Objectives Smoking disrupts oxidative balance and is a major risk factor for periodontitis. Forkhead box protein O‐1 (FoxO‐1) regulates antioxidant defense, yet its contribution to smoking‐associated periodontal breakdown is unclear. This cross‐sectional case–control study assessed reactive oxygen species (ROS), matrix metalloproteinase‐9 (MMP‐
Fatma Oner, Fatma Soysal, Ceren Gokmenoglu, Muhittin A. Serdar, Zeliha Guney   +4 more
wiley   +1 more source

Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease. [PDF]

Int J Mol Sci
Krekora J, Drożdż J, Pawlowska E, Blasiak J.   +3 more
europepmc   +1 more source

Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol. [PDF]

Front Pharmacol
Amegble K, Liu L, Duan T, Fang K, Petronek MS, Bailey CK.   +5 more
europepmc   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Sirtuins as Molecular Mediators of Caloric Restriction in the Pancreas: Implications for β-Cell Function, Metabolism, and Longevity. [PDF]

Int J Mol Sci
Zgutka K, Mikołajek-Bedner W, Szumilas K, Tarnowski M.   +3 more
europepmc   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis. [PDF]

Ren Fail
Deng Q, Li C, Luo J, Yin M, Qian S, Li L.   +5 more
europepmc   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source