Results 201 to 210 of about 18,502 (257)

Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics

Macromolecular Bioscience, Volume 26, Issue 7, July 2026.
Nucleic acid therapeutics have been investigated to expand their applications to renal genetic disorders. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys.
Jun Hyuk Lee, Junku Han, Sehwan Park, Hyejung Mok   +3 more
wiley   +1 more source

Sirtuins Contribute to the Migraine-Stroke Connection. [PDF]

Int J Mol Sci
Krekora J, Fila M, Mitus-Kenig M, Pawlowska E, Ciupinska J, Blasiak J.   +5 more
europepmc   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

NAD⁺ Homeostasis and Autophagy: Integrated Control Through Nutrient Signaling in Yeast and Mammals. [PDF]

Cells
McDaniel M, Lee LH, Lin SJ.
europepmc   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Molecular mechanisms underlying Parkinson's disease and role of phytochemicals, α-synuclein, sirtuins, and incretin mimetics in potential therapy. [PDF]

Front Pharmacol
Juthi SS, Ansari P, Ahmed MF, Khan JT, Seidel V, Kumar S, Kumari R, McKillop A, Abdel-Wahab YHA, Flatt PR.   +9 more
europepmc   +1 more source

Atherosclerosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Molecular factors, like transforming growth factor beta (TGF‐β), mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase (PI3K), or cyclin‐dependent kinases (CDKs) 5 and 9, are essential modulators of atherosclerotic lesions. The novel, promising strategies for atherosclerosis treatment include therapies based on small interfering RNA (siRNA)
Jonatan Kaszubski, Agata Wawrzyniak, Maciej Gagat, Agnieszka Żuryń   +3 more
wiley   +1 more source

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone. [PDF]

Aging Cell
Nguyen BL, Kehmeier MN, Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Rosenberry R, Keller AC, Steinke K, Miles K, Guerrero L, Kohrt WM, Reusch J, Clayton ZS, Moreau KL.   +14 more
europepmc   +1 more source

BGP‐15 Treatment Improves Follicle Growth and Alters Collagen Deposition in Mouse Transplanted Ovaries

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
Ex vivo treatment with BGP‐15 promotes follicular activation and gene regulation (Sirt1, Sirt3, NAMPT, Pten, Amh). After transplantation, BGP‐15 reduces atresia and collagen deposition, stimulating follicular growth, survival, and neoangiogenesis at timepoints of 6 and 22 days post‐transplantation.
Luiza Aparecida Ansaloni Chagas Pereira, Larissa Aline Freitas, Camila Stefane Ferreira, Karine Stephany Serpa Amaral Dias, Paulo Henrique Almeida Campos‐Junior   +4 more
wiley   +1 more source

Deacetylation of SOD3 by sirtuins restores furin cleavage. [PDF]

Redox Biochem Chem
Mitchem EC, Harris PS, Michel CR, McGinnis CD, Ray S, Mallela KMG, Roede JR, Petersen SV, Nozik ES, Fritz KS.   +9 more
europepmc   +1 more source