Results 191 to 200 of about 18,502 (257)

Exercise‐Induced Extracellular Vesicles as Mediators of Mitochondrial Biogenesis and Insulin Sensitivity in Metabolic Adaptation

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Exercise stimulates the release of extracellular vesicles from metabolically active tissues. These vesicles transport regulatory cargos, including microRNAs, proteins, lipids, and metabolites, to target organs such as skeletal muscle, adipose tissue, liver, and vascular tissues.
Jian Wang, Lei Wu
wiley   +1 more source

Unraveling Network Pharmacology-Based Therapeutics of Anthranilate Sulfonamides via Sirtuins/FOXO3a Cascade in Alzheimer's Disease. [PDF]

J Neurochem
Ruankham W, Prachayasittikul V, Pingaew R, Jeungprasopsuk W, Tantimongcolwat T, Prachayasittikul V, Prachayasittikul S, Phopin K.   +7 more
europepmc   +1 more source

Virtual Nature, Metaverse, and NAD⁺: A Narrative Review for Health Planning and Healthy Ageing

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Digital experiences—including virtual reality (VR), the metaverse, and exergaming—shape stress, mental health, and physical activity. While nature‐related and urban digital experiences influence health behaviors through different pathways, their impact on nicotinamide adenine dinucleotide (NAD⁺), a key mediator of cellular ...
Tohru Nakajima, Yukio Koibuchi
wiley   +1 more source

Correction: Zgutka et al. Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus. <i>Pharmaceuticals</i> 2025, <i>18</i>, 41. [PDF]

Pharmaceuticals (Basel)
Zgutka K, Tkacz M, Grabowska M, Mikołajek-Bedner W, Tarnowski M.   +4 more
europepmc   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Plasma levels of sirtuin 1 and sirtuin 2 in ascending aortic aneurysm patients - a comparative study. [PDF]

Cardiol J
Krekora J, Matuszewska-Brycht O, Fryczak J, Stępiński P, Krejca M, Siejka A, Kaczmarek D, Merks P, Drożdż J.   +8 more
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

PARP inhibitors target cellular energy metabolism: Mechanisms of action and clinical implications. [PDF]

Transl Oncol
Li J, Mu D, Li J, Lan M, Wu W, Zhang S, Dai Y.   +6 more
europepmc   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Traditional Health Practices May Promote Nrf2 Activation Similar to Exercise. [PDF]

Int J Mol Sci
Kolb H, Martin S, Kempf K.
europepmc   +1 more source