Results 221 to 230 of about 18,502 (257)
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Expert Opinion on Therapeutic Patents, 2009
Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
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Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
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Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
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Annual Review of Biochemistry, 2006
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
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Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
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2021
Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
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Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
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The Substrate Specificity of Sirtuins
Annual Review of Biochemistry, 2016Sirtuins are NAD + -dependent enzymes universally present in all organisms, where they play central roles in regulating numerous biological processes.
Bheda, P. +3 more
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Flavonoids as Sirtuin Modulators
Current Topics in Medicinal Chemistry, 2022Abstract: Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III histone deacetylases. So far, seven sirtuin genes (SIRTS 1–7) have been identified and characterized in mammals and also known to occur in bacteria and eukaryotes.
Deniz, FATMA SEZER +2 more
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The Many Faces of Sirtuins: Sirtuins and the Warburg effect
Nature Medicine, 2014Metabolic regulators that permit adaptation to changes in caloric intake have been shown to be needed to protect from age-related disorders. Sirtuins play a crucial part in this program, impinging on not only aging but also other diseases. New findings are uncovering the multifaceted activity of sirtuins in living organisms and their effects on ...
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Epigenetics, sirtuins and osteoarthritis
Joint Bone Spine, 2012Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA).
Gabay, Odile, Sanchez, Christelle
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The brain, sirtuins, and ageing
Nature Reviews Neuroscience, 2017In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level.
Akiko, Satoh +2 more
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Mitochondrial sirtuins in the heart
Heart Failure Reviews, 2016Sirtuins (SIRTs) are NAD(+)-dependent enzymes that catalyze deacylation of protein lysine residues. In mammals, seven sirtuins have been identified, SIRT1-7. SIRT3-5 are mainly or exclusively localized within mitochondria and mainly participate in the regulation of energy metabolic pathways.
Heiko Bugger +2 more
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