Results 241 to 250 of about 22,350 (290)

Oxidative Stress, Mitochondrial Homeostasis, and Sirtuins in Atrial Fibrillation. [PDF]

Int J Mol Sci
Krekora J, Pawlowska E, Derwich M, Drożdż J, Blasiak J.   +4 more
europepmc   +1 more source

Pyrroloquinoline Quinone Attenuates Traumatic Brain Injury‐Induced Secondary Damage by Activating PINK1/Parkin‐Mediated Mitophagy and Suppressing ASS1/CPS1‐Driven Arginine Biosynthesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pyrroloquinoline quinone (PQQ) attenuates traumatic brain injury in mice. Multi‐omics integration and molecular docking reveal that PQQ activates PINK1/Parkin‐mediated mitophagy to restore mitochondrial homeostasis while suppressing ASS1/CPS1‐driven arginine biosynthesis to dampen neuroinflammation, identifying a dual‐axis therapeutic mechanism for TBI.
Yanan He, Lu Yu, Yixun Lu, Zhikang Zhou, Ao Li, Lu Wang, Zhili Huang, Yanhong Liu, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Targeting NAD Homeostasis: Compartmentalization, Quantification, and Modulation. [PDF]

Metabolites
Nobile M, Fontanini V, Serrao S, Burtscher J, Re F, Paglia G.   +5 more
europepmc   +1 more source

Nutritional Regulation of Ovarian Bioenergetics: Implications for Reproductive Aging and Female Infertility. [PDF]

Nutrients
Kim J, Lee J.
europepmc   +1 more source

Evaluation of Molecular Responses and Longevity Markers in <i>Acheta domesticus</i> Following Combined Resveratrol and Nanodiamond Exposure. [PDF]

Int J Mol Sci
Ziętara-Krzyk P, Flasz B, Augustyniak M.   +2 more
europepmc   +1 more source

Filament formation and NAD processing by noncanonical human FAM118 sirtuins. [PDF]

Nat Struct Mol Biol
Baretić D, Missoury S, Patel K, Martinez M, Coste F, Zhu K, Smith R, Kopasz AG, Lu Y, Bigot N, Chapuis C, Riou R, Đukić N, Goffinont S, Pressoir V, Patačko S, Timinszky G, Delarue M, Castaing B, Ahel D, Mikoč A, Huet S, Ahel I, Suskiewicz MJ.   +23 more
europepmc   +1 more source

Correction: Zgutka et al. Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus. <i>Pharmaceuticals</i> 2025, <i>18</i>, 41. [PDF]

Pharmaceuticals (Basel)
Zgutka K, Tkacz M, Grabowska M, Mikołajek-Bedner W, Tarnowski M.   +4 more
europepmc   +1 more source

Retraction: The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway. [PDF]

Biosci Rep
He J, Zhang A, Song Z, Guo S, Chen Y, Liu Z, Zhang J, Xu X, Liu J, Chu L.   +9 more
europepmc   +1 more source