Results 241 to 250 of about 30,210 (302)

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Sirtuins and tumor immunity: mechanistic insights, immunotherapy prospects, and therapeutic horizons. [PDF]

Front Immunol
Gu J, Liu S, Xiao W, Qu W.
europepmc   +1 more source

Clinical Outcomes and Correlation With Biochemical Control in Hydroxocobalamin‐Treated Patients With Early‐Onset Cobalamin C Disease

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Cobalamin C (cblC) disease is the most common disorder of Vitamin B12 activation. The early‐onset form presents within the first few months of life, with some patients identified through newborn screening (NBS). However, despite early detection and optimal treatment, patient outcomes remain poor, with intellectual impairment and progressive ...
Arthavan Selvanathan, Ashley Hertzog, Jacqui Russell, Rosie Junek, Carolyn Ellaway, Kate Lichkus, Adviye Ayper Tolun, Kaustuv Bhattacharya   +7 more
wiley   +1 more source

Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy. [PDF]

Ann Med
Thanuskodi Rajakumar A, Kodiveri Muthukaliannan G.   +1 more
europepmc   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Managing the negative regulation of Sirtuins in a murine model of premature ovarian failure: focusing on the key roles of antioxidants. [PDF]

J Ovarian Res
Nasab SE, Shahhoseini M, Tavana S.
europepmc   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer. [PDF]

NPJ Aging
Grzeczka A, Skowronska A, Sepe S, Skowronski MT, Kordowitzki P.   +4 more
europepmc   +1 more source

Effects of Psyllium Husk on Metabolic Regulators, Insulin Resistance, and SIRT6 in Liver and Muscle of Type 2 Diabetic Rats

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
The effects of psyllium husk supplementation on metabolic regulators, insulin resistance markers, and SIRT6 expression in the liver and skeletal muscle tissues of type 2 diabetic rats were investigated. PHP demonstration has significant beneficial effects by partially improving metabolic dysfunctions and increasing antioxidant capacity in T2DM ...
Furkan Ümit, Gülay Çiftci, Burcu Onuk, Recai Aci, Özüm Çaka, Alper Çiftci   +5 more
wiley   +1 more source

Placental Expression of Sirtuins in Women with Gestational Diabetes. [PDF]

Genes (Basel)
Czerewaty M, Ustianowski Ł, Kiełbowski K, Bakinowska E, Safranow K, Tarnowski M, Sroczyński T, Pawlik A.   +7 more
europepmc   +1 more source