Results 231 to 240 of about 22,350 (290)

Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback. [PDF]

J Comp Physiol B
O'Brien KM, Cominassi L, Robine S, Marbacher P, Ressel K.   +4 more
europepmc   +1 more source

Dual miRNA‐Mediated Axes Act in Concert in the Antioxidant Action of Eicosapentaenoic Acid: let‐7c‐3p/TFAM Drives Mitochondrial Biogenesis While miR‐34c‐5p/SIRT1 Potentiates Enzymatic Defenses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Previous transcriptomic analysis revealed that eicosapentaenoic acid (EPA) alters miRNA expression in HepG2 cells. Two key miRNA‐mRNA axes mediating EPA's antioxidant effects were identified. EPA was found to downregulate let‐7c‐3p, which directly targets mitochondrial transcription factor A (TFAM).
Haiqi Wang, Yanqi Lin, Yuanyuan Li, Xiaowen Wu, Jingyu Lin, Shiying Huang, Guiling Li   +6 more
wiley   +1 more source

The deacetylase Sir2 is the primary sensor driving transcriptional changes in response to low NAD+ in the yeast Kluyveromyces lactis. [PDF]

Genetics
Acharjee M, Humphrey K, Lactaoen V, Karageorgiou C, Liu B, Gokcumen O, Rusche LN.   +6 more
europepmc   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans. [PDF]

Genetics
Chang SM, Franklin LP, Sattar S, Moro CA, DeGennaro MV, LaGanke NG, Hanna-Rose W.   +6 more
europepmc   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Mechanistic and preclinical evaluation of SIRT3 as a therapeutic target in melanoma. [PDF]

J Derm Oncol
Anaya Aldrete KB, Ndiaye MA, Guzmán-Pérez G, Zaemisch GR, Singh CK, Chhabra G, Ahmad N.   +6 more
europepmc   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Protein acetylation in atherosclerosis: beyond inflammation to core cellular processes and therapeutic potential. [PDF]

Front Immunol
Dong Z, Zhou Y, Gao Y, Guo R, He X, Deng Y, Chen Y, Zhu Q, Wei J, Guo Z.   +9 more
europepmc   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source