Results 261 to 270 of about 22,350 (290)

Epigenetics, sirtuins and osteoarthritis

Joint Bone Spine, 2012
Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA).
Gabay, Odile, Sanchez, Christelle
openaire   +2 more sources

Mitochondrial sirtuins in the heart

Heart Failure Reviews, 2016
Sirtuins (SIRTs) are NAD(+)-dependent enzymes that catalyze deacylation of protein lysine residues. In mammals, seven sirtuins have been identified, SIRT1-7. SIRT3-5 are mainly or exclusively localized within mitochondria and mainly participate in the regulation of energy metabolic pathways.
Heiko Bugger, Constantin N. Witt, Christoph Bode   +2 more
openaire   +3 more sources

C. elegans Sirtuins

2013
The nematode Caenorhabditis elegans (C. elegans) has four Sir2 paralogs, sir-2.1, sir-2.2, sir-2.3, and sir-2.4. Thus far, most of the research tools to study worm sirtuins have been developed for sir-2.1, due to its homology to yeast SIR2 and human SIRT1.
Viswanathan, Mohan, Tissenbaum, Heidi A.
openaire   +3 more sources

Sirtuins and the prevention of immunosenescence

2021
Aging of hematopoietic stem cells (HSCs) has been largely described as one underlying cause of senescence of the immune-hematopoietic system (immunosenescence). A set of well-defined hallmarks characterizes aged HSCs contributing to unbalanced hematopoiesis and aging-associated functional alterations of both branches of the immune system.
openaire   +2 more sources

Sirtuins

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
openaire   +2 more sources

Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators

International Journal of Molecular Sciences, 2021
Adriana Kubis, Agnieszka Piwowar, Katarzyna Sołkiewicz   +2 more
exaly  

Mitochondrial sirtuins, metabolism, and aging

Journal of Genetics and Genomics, 2022
Guang-Hui Liu, Jing Qu, Zhejun Ji
exaly  

Sirtuins: The NAD + -Dependent Multifaceted Modulators of Inflammation

Antioxidants and Redox Signaling, 2023
Aldo José Calliari, Juliana Camacho-Pereira, Carlos Escande   +2 more
exaly  

Sirtuins: Research advances on the therapeutic role in acute kidney injury

Phytomedicine, 2022
Chunpeng Wan, Tingdong Yan, Yi Cai
exaly  

Mitochondrial Sirtuins in Parkinson’s Disease

Neurochemical Research, 2022
Huaijun Tu, Ling He
exaly