Results 271 to 280 of about 30,210 (302)
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The Many Faces of Sirtuins: Sirtuins and the Warburg effect
Nature Medicine, 2014Metabolic regulators that permit adaptation to changes in caloric intake have been shown to be needed to protect from age-related disorders. Sirtuins play a crucial part in this program, impinging on not only aging but also other diseases. New findings are uncovering the multifaceted activity of sirtuins in living organisms and their effects on ...
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Epigenetics, sirtuins and osteoarthritis
Joint Bone Spine, 2012Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA).
Gabay, Odile, Sanchez, Christelle
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The brain, sirtuins, and ageing
Nature Reviews Neuroscience, 2017In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level.
Akiko, Satoh +2 more
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Mitochondrial sirtuins in the heart
Heart Failure Reviews, 2016Sirtuins (SIRTs) are NAD(+)-dependent enzymes that catalyze deacylation of protein lysine residues. In mammals, seven sirtuins have been identified, SIRT1-7. SIRT3-5 are mainly or exclusively localized within mitochondria and mainly participate in the regulation of energy metabolic pathways.
Heiko Bugger +2 more
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A Review on SIRtuins in Diabetes
Current Pharmaceutical Design, 2017Type-2 Diabetes is a long lasting disease characterized by high glucose concentration in the blood due to insulin resistance. One of the recent treatment strategies is using activators against SIRT-1, which has been in clinical trials. Hence, it is necessary to know the effects of the SIRT-1 modulators against various metabolic pathways.Many cellular ...
R, Aditya +4 more
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Sirtuins' modulation of autophagy
Journal of Cellular Physiology, 2013AbstractThe sirtuin family of class III histone deacetylases has been extensively implicated in modulating a myriad of cellular processes, including energy metabolism, stress response, cell/tissue survival and malignancy. Recent studies have also identified multifaceted roles for Sirt1 and Sirt2 in the regulation of autophagy.
Fanny, Ng, Bor Luen, Tang
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Sirtuins, epigenetics and longevity
Ageing Research Reviews, 2017Aging of organisms begins from a single cell at the molecular level. It includes changes related to telomere shortening, cell senescence and epigenetic modifications. These processes accumulate over the lifespan. Research studies show that epigenetic signaling contributes to human disease, tumorigenesis and aging.
Mateusz, Wątroba +5 more
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Sirtuins and the prevention of immunosenescence
2021Aging of hematopoietic stem cells (HSCs) has been largely described as one underlying cause of senescence of the immune-hematopoietic system (immunosenescence). A set of well-defined hallmarks characterizes aged HSCs contributing to unbalanced hematopoiesis and aging-associated functional alterations of both branches of the immune system.
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A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism
Life Sciences, 2021Shahab Shahgaldi +1 more
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