S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]
The EMBO JournalSororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient.
Meiqian Jiang +15 more
doaj +3 more sources
Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion [PDF]
Nature Communications, 2020 WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Janne J M Van Schie +2 more
exaly +3 more sources
SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis [PDF]
Nature Communications, 2019 During cell division, Soronin antagonises WAPL to prevent premature loss of sister chromatid cohesion. Here the authors show that, despite a lack of sequence similarity, the Arabidopsis SWI1 protein functions as a novel Soronin-like WAPL antagonist ...
Chao Yang +2 more
exaly +3 more sources
LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. [PDF]
PLoS Biology, 2012 Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase ...
Yonatan B Tzur +7 more
doaj +11 more sources
Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork [PDF]
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
doaj +2 more sources
Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers. [PDF]
PLoS Genetics, 2007 The cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis. They establish sister chromatid cohesion between duplicating DNA molecules during S-phase, but they also have an important role during postreplicative double-
Ana M Valdeolmillos +10 more
doaj +3 more sources
Chromatin assembly factor-1 preserves genome stability in ctf4∆ cells by promoting sister chromatid cohesion [PDF]
Cell Stress, 2023 Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF-1), a central
Nagham Ghaddar +3 more
doaj +2 more sources
Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. [PDF]
PLoS Genetics, 2016 Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division.
T Niroshini Senaratne +3 more
doaj +3 more sources
Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion [PDF]
mSphere, 2018 Recent studies have demonstrated that aberrant sister chromatid cohesion causes genomic instability and hence is responsible for the development of a tumor.
Nidhi Khurana +4 more
doaj +2 more sources
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion. [PDF]
Nat Commun, 2019 Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR).
Ortega P +2 more
europepmc +3 more sources