Results 91 to 100 of about 18,693 (245)
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
BioEssays, Volume 48, Issue 1, January 2026.Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source
Transcription facilitates sister chromatid cohesion on chromosomal arms [PDF]
Nucleic Acids Research, 2016 Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic. Here, we show two populations of functionally distinct cohesin on chromosomal arms using a combination ...
Bhardwaj, S +3 more
openaire +2 more sources
Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]
, 2017 Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D +1 more
core +1 more source
Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis
BioEssays, Volume 48, Issue 1, January 2026.The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley +1 more source
Chromosome Organization in Early Meiotic Prophase
Frontiers in Cell and Developmental Biology, 2021 One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
doaj +1 more source
IET Systems Biology, Volume 20, Issue 1, January/December 2026.Colorectal cancer (CRC) has high incidence and mortality, with conventional chemotherapy having severe side effects and drug resistance; traditional Chinese medicine‐derived nitidine chloride (NC) has anti‐tumour activity but unknown anti‐CRC mechanisms, whereas centromere‐associated protein E (CENPE), aberrantly expressed in malignancies, is a ...
Bin Li +10 more
wiley +1 more source
An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic
Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 35-49, January 2026.ABSTRACT Meiotic recombination is an essential process for shuffling genetic diversity in sexually reproducing organisms, can vary within and between individuals in response to intrinsic and extrinsic factors, and can be heritable. Interestingly, recombination rate has been found to vary with age in some species, but to date, there have been no ...
Evelyn Jade +5 more
wiley +1 more source
Genetic Dissection of Parallel Sister-Chromatid Cohesion Pathways [PDF]
Genetics, 2007 Abstract Sister-chromatid cohesion, the process of pairing replicated chromosomes during mitosis and meiosis, is mediated through the essential cohesin complex and a number of nonessential cohesion genes, but the specific roles of these nonessential genes in sister-chromatid cohesion remain to be clarified.
Hong, Xu, Charles, Boone, Grant W, Brown
openaire +2 more sources
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. [PDF]
, 2013 Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF(Cdc4).
Diedrich, Jolene K +4 more
core +1 more source
Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica
New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns +6 more
wiley +1 more source