Results 101 to 110 of about 18,693 (245)
A Long Noncoding RNA Regulates Sister Chromatid Cohesion. [PDF]
Mol Cell, 2016 Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types.
Marchese FP +10 more
europepmc +7 more sources
A role for Separase in telomere protection [PDF]
, 2016 Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity and are assembled independently of the sequence. Fly telomeres are protected by the terminin complex that localizes and functions exclusively
Bosso, Giuseppe +9 more
core +1 more source
The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability
Cytoskeleton, Volume 82, Issue 12, Page 804-814, December 2025.ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou +6 more
wiley +1 more source
ATRX: From Chromatin Remodeling to Disease
genesis, Volume 63, Issue 6, December 2025.ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Mauro Magaña‐Acosta +1 more
wiley +1 more source
PLoS Biology, 2020 During meiosis, chromosomes adopt a specialized organization involving assembly of a cohesin-based axis along their lengths, with DNA loops emanating from this axis.
Alexander Woglar +5 more
doaj +1 more source
Health Science Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background and Aims Chromosomal nondisjunction is the primary etiology of Down syndrome; however, genetic variations, environmental causes, and maternal etiologies also contribute to a great extent. The objective of this review is to evaluate these multifaceted factors during pregnancy.
Md. Sohel Rana +2 more
wiley +1 more source
Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
Nature Communications, 2018 During meiosis, step-wise release of sister chromatid cohesion mediated by REC-8 cohesin is required for the formation of haploid gametes. Here, the authors show that in C.
Nuria Ferrandiz +10 more
doaj +1 more source
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
core +4 more sources