Results 111 to 120 of about 18,693 (245)

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, Volume 292, Issue 23, Page 6163-6181, December 2025.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

Structural evidence for Scc4-dependent localization of cohesin loading

eLife, 2015
The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2NIPBL/Scc4Mau2 (Scc2/4), which loads cohesin onto DNA and determines its ...
Stephen M Hinshaw, Vasso Makrantoni, Alastair Kerr, Adèle L Marston, Stephen C Harrison   +4 more
doaj   +1 more source

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint [version 1; peer review: 2 approved]

F1000Research, 2020
The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere ...
Angela Flavia Serpico, Domenico Grieco
doaj   +1 more source

SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? [PDF]

, 1999
The assembly of mitotic chromosomes is a fundamental cellular event that ensures the faithful segregation of genetic information during cell division. It involves two processes that are, in principle, mechanistically distinct.
Hirano, T.
core   +1 more source

Lactylation Genes LDHA and LDHC Alleviate Osteoarthritis by Reducing Specific B‐Cell Expression: Mechanistic Exploration and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT This study aims to elucidate the correlation between the lactylation‐related genes and the progression of knee osteoarthritis (KOA). Integrating genome‐wide association study data and expression quantitative trait locus data, Mendelian randomisation (MR) and summary‐data‐based MR analyses assessed the correlation between lactylation‐related ...
Jingkai Di, Zijian Guo, Yijing Di, Tingting Chen, Yingda Qin, Xinglong Xing, Chuan Xiang   +6 more
wiley   +1 more source

Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

PLoS ONE, 2010
Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown.
Jordan B Rapp, Chiaki Noguchi, Mukund M Das, Lisa K Wong, Alison B Ansbach, Allyson M Holmes, Benoit Arcangioli, Eishi Noguchi   +7 more
doaj   +1 more source

K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Under endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). During the UPR, the cohesin complex at the promoter of cell proliferation‐related genes undergoes K29‐linked ubiquitination, recruiting the cohesin release factor WAPL to release cohesin, leading to transcriptional downregulation and inhibition of cell growth ...
Qiushuang Zhang, Xucong Teng, Yicong Dai, Yuncong Wu, Hongwei Hou, Jinghong Li   +5 more
wiley   +1 more source

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]

, 2014
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ, Bähler, J, Deegan, RS, Hulme, L, Humphrey, TC, Hussey, S, Kasparek, TR, Marguerat, S, Nakagawa, T, Pai, CC, Sarkar, S, Tinline-Purvis, H, Walker, CA, Wee, BY   +13 more
core   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, Volume 47, Issue 11, November 2025.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source

DNA damage‐induced sister chromatid cohesion

The FASEB Journal, 2007
Correct chromosome segregation and DNA damage repair are essential processes required for the stable propagation of the genome. Failure of either leads to genome instability and is linked to human disease. We investigate the protein complex cohesin that represents a functional connection between chromosome segregation and DNA double‐strand break (DSB ...
Camilla Sjögren, Katsuhiko Shirahige, Charlotte Karlsson, Lena Ström   +3 more
openaire   +1 more source